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The genetic architecture of autistic traits and negative symptoms in non-affective first-episode psychosis: an exploratory longitudinal study.

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Title: The genetic architecture of autistic traits and negative symptoms in non-affective first-episode psychosis: an exploratory longitudinal study.
Authors: Mezquida G; Serra-Hunter Lecturer Fellow, Department of Clinical Foundations, Pharmacology Unit, University of Barcelona; CIBERSAM-ISCIII; Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), C/Casanova 143, CP 08036, Spain. Electronic address: mezquida@recerca.clinic.cat., Perez-Ramos A; Centre for Biomedical Research in Mental Health (CIBERSAM), ISCI-III, Madrid, Spain; Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, University of Cadiz, Cadiz, Spain., Guasch-Capella N; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, Barcelona, Spain; University of Barcelona, Medicine Department, Barcelona, Spain., Forte MF; Bipolar and Depressive Disorders Unit, Neuroscience Institute, Hospital Clinic de Barcelona, Barcelona, Spain. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Parellada M; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM-ISCIII, School of Medicine, Universidad Complutense, Madrid, Spain., Amoretti S; Psychiatry, Mental Health and Addictions Group, Vall d'Hebron Research Institute (VHIR), Instituto de Investigación Sanitaria Acreditado Instituto de Investigación - Hospital Universitario Vall d'Hebron (IR-HUVH), Barcelona, Catalonia, CIBERSAM-ISCIII, Spain., Serra-Navarro M; Bipolar and Depressive Disorders Unit, Neuroscience Institute, Hospital Clinic de Barcelona, Barcelona, Spain. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, CIBERSAM-ISCIII, Spain., Galvañ J; Department of Psychiatry, Hospital Universitario de Navarra; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain., Cuesta MJ; Grup MERITT, Institut de Recerca Sant Joan de Déu. Parc Sanitari Sant Joan de Déu, CIBERSAM-ISCIII., Mané A; Department of Child and Adolescent Psychiatry and Psychology, 2021SGR01319, Hospital Clínic de Barcelona. Fundació Clínic-IDIBAPS; CIBERSAM-ISCIII; Department of Medicine, Institute of Neuroscience, University of Barcelona, Spain., la Serna E; Department of Genetics, Microbiology, and Statistics, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain, Biomedicine Institute of the Universitat de Barcelona (IBUB), Spain; Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, CIBERSAM-ISCIII, Spain., Mitjans M; Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, CIBERSAM-ISCIII; Departament de Medicina, Institut de Neurociències (UBNeuro), Universitat de Barcelona., Bioque M; Bipolar and Depressive Disorders Unit, Hospital Clínic de Barcelona; Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain. Electronic address: mbioque@clinic.cat., García-Rizo C; Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; CIBERSAM-ISCIII; Departament de Medicina, Institut de Neurociències (UBNeuro), Universitat de Barcelona, Barcelona, Spain., Segura AG; Bipolar and Depressive Disorders Unit, Hospital Clínic de Barcelona; Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Catalonia, Barcelona, Spain., Group AP; PEPs Group: A. Martínez-Pinteño, V. Llorca, J. González Peñas, L. Pina-Camacho, A. Roldán, A. González-Pinto, I. Zorrilla, P. Ruiz, C. De-la-Camara, M. J. Escartí, O. Rivero, L. Prats, C. Romans, E. Vieta, A. Martinez-Aran, J. Castro-Fornieles, I. Baeza, M. P. Portilla, R. Sagarra, A. Zabala, R. Rodriguez-Jimenez, M. A. Alvarez-Mon, J. Usall, S. Sarró, E. Pomarol-Clotet, Á. Ibáñez, A. M. Sánchez-Torres, V. Balanzá-Martínez.
Source: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2026 May 17; Vol. 111, pp. 112859. Date of Electronic Publication: 2026 May 17.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9111390 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7862 (Electronic) Linking ISSN: 0924977X NLM ISO Abbreviation: Eur Neuropsychopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The genetic architecture of autistic traits and negative symptoms in non-affective first-episode psychosis: an exploratory longitudinal study.
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  Data: <searchLink fieldCode="AU" term="%22Mezquida+G%22">Mezquida G</searchLink>; Serra-Hunter Lecturer Fellow, Department of Clinical Foundations, Pharmacology Unit, University of Barcelona; CIBERSAM-ISCIII; Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), C/Casanova 143, CP 08036, Spain. Electronic address: mezquida@recerca.clinic.cat.<br /><searchLink fieldCode="AU" term="%22Perez-Ramos+A%22">Perez-Ramos A</searchLink>; Centre for Biomedical Research in Mental Health (CIBERSAM), ISCI-III, Madrid, Spain; Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, University of Cadiz, Cadiz, Spain.<br /><searchLink fieldCode="AU" term="%22Guasch-Capella+N%22">Guasch-Capella N</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, Barcelona, Spain; University of Barcelona, Medicine Department, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Forte+MF%22">Forte MF</searchLink>; Bipolar and Depressive Disorders Unit, Neuroscience Institute, Hospital Clinic de Barcelona, Barcelona, Spain. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Parellada+M%22">Parellada M</searchLink>; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM-ISCIII, School of Medicine, Universidad Complutense, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Amoretti+S%22">Amoretti S</searchLink>; Psychiatry, Mental Health and Addictions Group, Vall d'Hebron Research Institute (VHIR), Instituto de Investigación Sanitaria Acreditado Instituto de Investigación - Hospital Universitario Vall d'Hebron (IR-HUVH), Barcelona, Catalonia, CIBERSAM-ISCIII, Spain.<br /><searchLink fieldCode="AU" term="%22Serra-Navarro+M%22">Serra-Navarro M</searchLink>; Bipolar and Depressive Disorders Unit, Neuroscience Institute, Hospital Clinic de Barcelona, Barcelona, Spain. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, CIBERSAM-ISCIII, Spain.<br /><searchLink fieldCode="AU" term="%22Galvañ+J%22">Galvañ J</searchLink>; Department of Psychiatry, Hospital Universitario de Navarra; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Cuesta+MJ%22">Cuesta MJ</searchLink>; Grup MERITT, Institut de Recerca Sant Joan de Déu. Parc Sanitari Sant Joan de Déu, CIBERSAM-ISCIII.<br /><searchLink fieldCode="AU" term="%22Mané+A%22">Mané A</searchLink>; Department of Child and Adolescent Psychiatry and Psychology, 2021SGR01319, Hospital Clínic de Barcelona. Fundació Clínic-IDIBAPS; CIBERSAM-ISCIII; Department of Medicine, Institute of Neuroscience, University of Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22la+Serna+E%22">la Serna E</searchLink>; Department of Genetics, Microbiology, and Statistics, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain, Biomedicine Institute of the Universitat de Barcelona (IBUB), Spain; Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, CIBERSAM-ISCIII, Spain.<br /><searchLink fieldCode="AU" term="%22Mitjans+M%22">Mitjans M</searchLink>; Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, CIBERSAM-ISCIII; Departament de Medicina, Institut de Neurociències (UBNeuro), Universitat de Barcelona.<br /><searchLink fieldCode="AU" term="%22Bioque+M%22">Bioque M</searchLink>; Bipolar and Depressive Disorders Unit, Hospital Clínic de Barcelona; Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain. Electronic address: mbioque@clinic.cat.<br /><searchLink fieldCode="AU" term="%22García-Rizo+C%22">García-Rizo C</searchLink>; Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; CIBERSAM-ISCIII; Departament de Medicina, Institut de Neurociències (UBNeuro), Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Segura+AG%22">Segura AG</searchLink>; Bipolar and Depressive Disorders Unit, Hospital Clínic de Barcelona; Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Catalonia, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Group+AP%22">Group AP</searchLink>; PEPs Group: A. Martínez-Pinteño, V. Llorca, J. González Peñas, L. Pina-Camacho, A. Roldán, A. González-Pinto, I. Zorrilla, P. Ruiz, C. De-la-Camara, M. J. Escartí, O. Rivero, L. Prats, C. Romans, E. Vieta, A. Martinez-Aran, J. Castro-Fornieles, I. Baeza, M. P. Portilla, R. Sagarra, A. Zabala, R. Rodriguez-Jimenez, M. A. Alvarez-Mon, J. Usall, S. Sarró, E. Pomarol-Clotet, Á. Ibáñez, A. M. Sánchez-Torres, V. Balanzá-Martínez.
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