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Few-shot learning-driven discovery of Lutein suppresses Th1-mediated inflammation via glucose metabolism.

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Title: Few-shot learning-driven discovery of Lutein suppresses Th1-mediated inflammation via glucose metabolism.
Authors: Yang LJ; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.; ZJU-Xinchang Joint Innovation Centre (TianMu Laboratory), Gaochuang Hi-Tech Park, Xinchang, 312500, China., Wei ZH; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Cao PJ; Beijing Life Science Academy, Beijing, 102200, China., Li ZB; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Li X; Beijing Life Science Academy, Beijing, 102200, China., Zhao JW; Beijing Life Science Academy, Beijing, 102200, China., Du YW; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Wang KH; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Zheng QH; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.; Taizhou Institute of Zhejiang University, Taizhou, 318000, China., He QJ; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Yang B; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. yang924@zju.edu.cn.; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou, 310058, China. yang924@zju.edu.cn.; Institute of Fundamental and Transdisciplinary Research, Zhejiang University, Hangzhou, 310058, China. yang924@zju.edu.cn.; School of Medicine, Hangzhou City University, Hangzhou, 310015, China. yang924@zju.edu.cn., Wang JJ; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. wjiajia@zju.edu.cn.; Taizhou Institute of Zhejiang University, Taizhou, 318000, China. wjiajia@zju.edu.cn.; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou, 310058, China. wjiajia@zju.edu.cn., Weng QJ; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. wengqinjie@zju.edu.cn.; Taizhou Institute of Zhejiang University, Taizhou, 318000, China. wengqinjie@zju.edu.cn.; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou, 310058, China. wengqinjie@zju.edu.cn.; Institute of Fundamental and Transdisciplinary Research, Zhejiang University, Hangzhou, 310058, China. wengqinjie@zju.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 May 18. Date of Electronic Publication: 2026 May 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Yang+LJ%22">Yang LJ</searchLink>; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.; ZJU-Xinchang Joint Innovation Centre (TianMu Laboratory), Gaochuang Hi-Tech Park, Xinchang, 312500, China.<br /><searchLink fieldCode="AU" term="%22Wei+ZH%22">Wei ZH</searchLink>; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Cao+PJ%22">Cao PJ</searchLink>; Beijing Life Science Academy, Beijing, 102200, China.<br /><searchLink fieldCode="AU" term="%22Li+ZB%22">Li ZB</searchLink>; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Beijing Life Science Academy, Beijing, 102200, China.<br /><searchLink fieldCode="AU" term="%22Zhao+JW%22">Zhao JW</searchLink>; Beijing Life Science Academy, Beijing, 102200, China.<br /><searchLink fieldCode="AU" term="%22Du+YW%22">Du YW</searchLink>; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Wang+KH%22">Wang KH</searchLink>; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Zheng+QH%22">Zheng QH</searchLink>; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.; Taizhou Institute of Zhejiang University, Taizhou, 318000, China.<br /><searchLink fieldCode="AU" term="%22He+QJ%22">He QJ</searchLink>; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Yang+B%22">Yang B</searchLink>; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. yang924@zju.edu.cn.; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou, 310058, China. yang924@zju.edu.cn.; Institute of Fundamental and Transdisciplinary Research, Zhejiang University, Hangzhou, 310058, China. yang924@zju.edu.cn.; School of Medicine, Hangzhou City University, Hangzhou, 310015, China. yang924@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+JJ%22">Wang JJ</searchLink>; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. wjiajia@zju.edu.cn.; Taizhou Institute of Zhejiang University, Taizhou, 318000, China. wjiajia@zju.edu.cn.; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou, 310058, China. wjiajia@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Weng+QJ%22">Weng QJ</searchLink>; Center for Drug Safety Evaluation and Research; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. wengqinjie@zju.edu.cn.; Taizhou Institute of Zhejiang University, Taizhou, 318000, China. wengqinjie@zju.edu.cn.; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou, 310058, China. wengqinjie@zju.edu.cn.; Institute of Fundamental and Transdisciplinary Research, Zhejiang University, Hangzhou, 310058, China. wengqinjie@zju.edu.cn.
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        Value: 10.1038/s41401-026-01822-9
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