Audiological Phenotype, Natural History, and Intervention in Chinese Patients With Auditory Neuropathy Caused by OTOF Variants.

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Title: Audiological Phenotype, Natural History, and Intervention in Chinese Patients With Auditory Neuropathy Caused by OTOF Variants.
Authors: Wang H; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.; These authors contributed equally to this work., Wu K; Department of Otorhinolaryngology-Head and Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, China.; These authors contributed equally to this work., Li J; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.; These authors contributed equally to this work., Zhang M; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China., Gao X; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China., Guan J; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China., Lan L; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China., Xie L; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China., Xiong F; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China., Zhang Q; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China., Xu X; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China., Li D; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China., Wang D; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China., Wang Q; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.
Source: Ear and hearing [Ear Hear] 2026 Jul-Aug 01; Vol. 47 (4), pp. 1067-1079. Date of Electronic Publication: 2026 May 18.
Publication Type: Journal Article
Journal Info: Publisher: Williams And Wilkins Country of Publication: United States NLM ID: 8005585 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-4667 (Electronic) Linking ISSN: 01960202 NLM ISO Abbreviation: Ear Hear Subsets: MEDLINE
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  Data: Audiological Phenotype, Natural History, and Intervention in Chinese Patients With Auditory Neuropathy Caused by OTOF Variants.
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  Data: <searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.; These authors contributed equally to this work.<br /><searchLink fieldCode="AU" term="%22Wu+K%22">Wu K</searchLink>; Department of Otorhinolaryngology-Head and Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, China.; These authors contributed equally to this work.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.; These authors contributed equally to this work.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Gao+X%22">Gao X</searchLink>; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Guan+J%22">Guan J</searchLink>; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lan+L%22">Lan L</searchLink>; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xie+L%22">Xie L</searchLink>; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xiong+F%22">Xiong F</searchLink>; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Audiovestibular Medicine, Senior Department of Otolaryngology, Head and Neck Surgery, the Sixth Medical Center of Chinese People's Liberation Army General Hospital, Medical School of Chinese PLA, Beijing, China.; Senior Department of Otolaryngology Head and Neck Surgery, the 6th Medical Center of Chinese PLA General Hospital, State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Chinese PLA General Hospital, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.
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