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Tryptophan pathway metabotypes associate with disease activity and immune-metabolic dysfunction in inflammatory bowel disease.

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Title: Tryptophan pathway metabotypes associate with disease activity and immune-metabolic dysfunction in inflammatory bowel disease.
Authors: Harris DMM; Institute of Clinical Molecular Biology, University Medical Center Schleswig-Holstein and Christian-Albrechts-University of Kiel, Kiel, Germany.; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.; Institute for Human Nutrition and Food Science, Division of Nutriinformatics, Christian-Albrechts-University of Kiel, Kiel, Germany., Bourgonje AR; The Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Braadland PR; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Norwegian PSC Research Center, Department of Transplantation Medicine, Oslo, University Hospital, Oslo, Norway., McShane C; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Welz L; Institute of Clinical Molecular Biology, University Medical Center Schleswig-Holstein and Christian-Albrechts-University of Kiel, Kiel, Germany.; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany., Waschina S; Institute for Human Nutrition and Food Science, Division of Nutriinformatics, Christian-Albrechts-University of Kiel, Kiel, Germany., Ibing S; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Hasso Plattner Institute, Digital Engineering Faculty, University of Potsdam, Potsdam, Germany., Tran F; Institute of Clinical Molecular Biology, University Medical Center Schleswig-Holstein and Christian-Albrechts-University of Kiel, Kiel, Germany.; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany., Sands BE; The Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dubinsky M; The Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Suarez-Farinas M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Argmann C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ueland PM; Bevital AS, Bergen, Norway., McCann A; Bevital AS, Bergen, Norway., Detlie TE; Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway., Bengtson MB; Department of Gastroenterology, Vestfold Hospital Trust, Tønsberg, Norway., Kristensen V; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Franke A; Institute of Clinical Molecular Biology, University Medical Center Schleswig-Holstein and Christian-Albrechts-University of Kiel, Kiel, Germany., Colombel JF; The Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rosenstiel P; Institute of Clinical Molecular Biology, University Medical Center Schleswig-Holstein and Christian-Albrechts-University of Kiel, Kiel, Germany., Croitoru K; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Division of Gastroenterology and Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Sokol H; Sorbonne Université, INSERM UMRS-938, Centre de Recherche Saint-Antoine, CRSA, AP-HP, F-75012 Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France.; Université Paris-Saclay, INRAe, AgroParisTech, Micalis Institute, Jouy-en-Josas, France., Turpin W; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Division of Gastroenterology and Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Hov JR; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway., Høivik ML; Norwegian PSC Research Center, Department of Transplantation Medicine, Oslo, University Hospital, Oslo, Norway.; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway., Ungaro RC; The Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Schreiber S; Institute of Clinical Molecular Biology, University Medical Center Schleswig-Holstein and Christian-Albrechts-University of Kiel, Kiel, Germany.; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany., Aden K; Institute of Clinical Molecular Biology, University Medical Center Schleswig-Holstein and Christian-Albrechts-University of Kiel, Kiel, Germany.; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 May 04. Date of Electronic Publication: 2026 May 04.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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  Data: Tryptophan pathway metabotypes associate with disease activity and immune-metabolic dysfunction in inflammatory bowel disease.
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  Data: <searchLink fieldCode="AU" term="%22Harris+DMM%22">Harris DMM</searchLink>; Institute of Clinical Molecular Biology, University Medical Center Schleswig-Holstein and Christian-Albrechts-University of Kiel, Kiel, Germany.; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.; Institute for Human Nutrition and Food Science, Division of Nutriinformatics, Christian-Albrechts-University of Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Bourgonje+AR%22">Bourgonje AR</searchLink>; The Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Braadland+PR%22">Braadland PR</searchLink>; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Norwegian PSC Research Center, Department of Transplantation Medicine, Oslo, University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22McShane+C%22">McShane C</searchLink>; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Welz+L%22">Welz L</searchLink>; Institute of Clinical Molecular Biology, University Medical Center Schleswig-Holstein and Christian-Albrechts-University of Kiel, Kiel, Germany.; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Waschina+S%22">Waschina S</searchLink>; Institute for Human Nutrition and Food Science, Division of Nutriinformatics, Christian-Albrechts-University of Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Ibing+S%22">Ibing S</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Hasso Plattner Institute, Digital Engineering Faculty, University of Potsdam, Potsdam, Germany.<br /><searchLink fieldCode="AU" term="%22Tran+F%22">Tran F</searchLink>; Institute of Clinical Molecular Biology, University Medical Center Schleswig-Holstein and Christian-Albrechts-University of Kiel, Kiel, Germany.; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Sands+BE%22">Sands BE</searchLink>; The Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Dubinsky+M%22">Dubinsky M</searchLink>; The Henry D. 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Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Schreiber+S%22">Schreiber S</searchLink>; Institute of Clinical Molecular Biology, University Medical Center Schleswig-Holstein and Christian-Albrechts-University of Kiel, Kiel, Germany.; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Aden+K%22">Aden K</searchLink>; Institute of Clinical Molecular Biology, University Medical Center Schleswig-Holstein and Christian-Albrechts-University of Kiel, Kiel, Germany.; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.
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