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A Genome-wide Association Study of Alzheimer's Disease and Dementia in a Large Multi-ancestry Military Cohort Identifies Many New Dementia-Associated Loci.

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Title: A Genome-wide Association Study of Alzheimer's Disease and Dementia in a Large Multi-ancestry Military Cohort Identifies Many New Dementia-Associated Loci.
Authors: Sherva R; National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, MA, 02130.; Department of Medicine (Biomedical Genetics) Boston University Chobanian & Avedisian, School of Medicine, Boston, MA, 02118, USA., Bayly H; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118., Zhang R; National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, MA, 02130., Harrington K; Million Veteran Program (MVP) Coordinating Center, VA Boston Healthcare System, Boston, MA, 02130.; Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118., Mez J; Department of Neurology, Boston University Chobanian & Avedisian, School of Medicine, Boston, MA.; Boston University Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Miller MW; National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, MA, 02130.; Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118., Tsuang D; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA., Wolf E; National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, MA, 02130.; Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118., Zeng Q; VA Washington DC Healthcare System, Washington, DC., Le Guen Y; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA.; Quantitative Sciences Unit, Department of Medicine, Stanford University School of Medicine, Stanford, CA., Tejeda M; Department of Medicine (Biomedical Genetics) Boston University Chobanian & Avedisian, School of Medicine, Boston, MA, 02118, USA., Gaziano JM; Million Veteran Program (MVP) Coordinating Center, VA Boston Healthcare System, Boston, MA, 02130.; Division of Aging, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts., Panizzon MS; Department of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA.; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, 92161., Hauger RL; Department of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA.; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, 92161., Merritt VC; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, 92161.; VA San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA, 92161., Farrer LA; Department of Medicine (Biomedical Genetics) Boston University Chobanian & Avedisian, School of Medicine, Boston, MA, 02118, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118.; Department of Neurology, Boston University Chobanian & Avedisian, School of Medicine, Boston, MA.; Boston University Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA., Logue MW; National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, MA, 02130.; Department of Medicine (Biomedical Genetics) Boston University Chobanian & Avedisian, School of Medicine, Boston, MA, 02118, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118.; Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118.
Corporate Authors: VA Million Veteran Program, MVP Cognitive Decline and Dementia During Aging Working Group
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 May 07. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A Genome-wide Association Study of Alzheimer's Disease and Dementia in a Large Multi-ancestry Military Cohort Identifies Many New Dementia-Associated Loci.
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  Data: <searchLink fieldCode="AU" term="%22Sherva+R%22">Sherva R</searchLink>; National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, MA, 02130.; Department of Medicine (Biomedical Genetics) Boston University Chobanian & Avedisian, School of Medicine, Boston, MA, 02118, USA.<br /><searchLink fieldCode="AU" term="%22Bayly+H%22">Bayly H</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, MA, 02130.<br /><searchLink fieldCode="AU" term="%22Harrington+K%22">Harrington K</searchLink>; Million Veteran Program (MVP) Coordinating Center, VA Boston Healthcare System, Boston, MA, 02130.; Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118.<br /><searchLink fieldCode="AU" term="%22Mez+J%22">Mez J</searchLink>; Department of Neurology, Boston University Chobanian & Avedisian, School of Medicine, Boston, MA.; Boston University Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Miller+MW%22">Miller MW</searchLink>; National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, MA, 02130.; Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118.<br /><searchLink fieldCode="AU" term="%22Tsuang+D%22">Tsuang D</searchLink>; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Wolf+E%22">Wolf E</searchLink>; National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, MA, 02130.; Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118.<br /><searchLink fieldCode="AU" term="%22Zeng+Q%22">Zeng Q</searchLink>; VA Washington DC Healthcare System, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Le+Guen+Y%22">Le Guen Y</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA.; Quantitative Sciences Unit, Department of Medicine, Stanford University School of Medicine, Stanford, CA.<br /><searchLink fieldCode="AU" term="%22Tejeda+M%22">Tejeda M</searchLink>; Department of Medicine (Biomedical Genetics) Boston University Chobanian & Avedisian, School of Medicine, Boston, MA, 02118, USA.<br /><searchLink fieldCode="AU" term="%22Gaziano+JM%22">Gaziano JM</searchLink>; Million Veteran Program (MVP) Coordinating Center, VA Boston Healthcare System, Boston, MA, 02130.; Division of Aging, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Panizzon+MS%22">Panizzon MS</searchLink>; Department of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA.; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, 92161.<br /><searchLink fieldCode="AU" term="%22Hauger+RL%22">Hauger RL</searchLink>; Department of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA.; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, 92161.<br /><searchLink fieldCode="AU" term="%22Merritt+VC%22">Merritt VC</searchLink>; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, 92161.; VA San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA, 92161.<br /><searchLink fieldCode="AU" term="%22Farrer+LA%22">Farrer LA</searchLink>; Department of Medicine (Biomedical Genetics) Boston University Chobanian & Avedisian, School of Medicine, Boston, MA, 02118, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118.; Department of Neurology, Boston University Chobanian & Avedisian, School of Medicine, Boston, MA.; Boston University Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Logue+MW%22">Logue MW</searchLink>; National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, MA, 02130.; Department of Medicine (Biomedical Genetics) Boston University Chobanian & Avedisian, School of Medicine, Boston, MA, 02118, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118.; Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118.
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        Value: 10.64898/2026.05.01.26352216
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        Text: English
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      – TitleFull: A Genome-wide Association Study of Alzheimer's Disease and Dementia in a Large Multi-ancestry Military Cohort Identifies Many New Dementia-Associated Loci.
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