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Development of NanoBRET cellular target engagement assays in primary neurons for activating mutants of p21-activated kinase 1.

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Title: Development of NanoBRET cellular target engagement assays in primary neurons for activating mutants of p21-activated kinase 1.
Authors: Capener JL; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Badillo-Martinez A; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA., Awada B; Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami, Miami, FL, USA., Davis-Gilbert ZW; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Kramer TW; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Blair CS; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Bashore FM; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Al-Ali H; Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami, Miami, FL, USA.; Department of Neurological Surgery, Peggy and Harold Katz Drug Discovery Center, Sylvester Cancer Comprehensive Center, and Frost Institute for Data Science and Computing, University of Miami, Miami, FL, USA., Axtman AD; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 06. Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 42146347
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Development of NanoBRET cellular target engagement assays in primary neurons for activating mutants of p21-activated kinase 1.
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  Data: <searchLink fieldCode="AU" term="%22Capener+JL%22">Capener JL</searchLink>; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.<br /><searchLink fieldCode="AU" term="%22Badillo-Martinez+A%22">Badillo-Martinez A</searchLink>; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Awada+B%22">Awada B</searchLink>; Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Davis-Gilbert+ZW%22">Davis-Gilbert ZW</searchLink>; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.<br /><searchLink fieldCode="AU" term="%22Kramer+TW%22">Kramer TW</searchLink>; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.<br /><searchLink fieldCode="AU" term="%22Blair+CS%22">Blair CS</searchLink>; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.<br /><searchLink fieldCode="AU" term="%22Bashore+FM%22">Bashore FM</searchLink>; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.<br /><searchLink fieldCode="AU" term="%22Al-Ali+H%22">Al-Ali H</searchLink>; Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami, Miami, FL, USA.; Department of Neurological Surgery, Peggy and Harold Katz Drug Discovery Center, Sylvester Cancer Comprehensive Center, and Frost Institute for Data Science and Computing, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Axtman+AD%22">Axtman AD</searchLink>; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 May 06. <i>Date of Electronic Publication: </i>2026 May 06.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.64898/2026.05.03.722513
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        Text: English
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              Text: 2026 May 06
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