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Rescuing the Function of Missense-Mutated Tumor Suppressor VHL using Stabilizing Small Molecules.

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Title: Rescuing the Function of Missense-Mutated Tumor Suppressor VHL using Stabilizing Small Molecules.
Authors: Fouad MA; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA., Parry CS; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.; MD/PhD Program, Lewis Katz School of Medicine at Temple University, Philadelphia, PA., Miller SA; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA., Malhotra S; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA., Doyle GA; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA., Shimabenga E; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA., Nurilloeva M; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA., Bondarenko E; Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia PA.; Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia PA., Andrianov GV; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA., Childers W; Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, PA., Blass BE; Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, PA., Makhov PB; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA., Whetstine JR; Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia PA.; Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia PA., Clapper ML; Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia PA., Golemis EA; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.; Department of Cancer and Cellular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA., Karanicolas J; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.; Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, PA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 29. Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Fouad+MA%22">Fouad MA</searchLink>; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.<br /><searchLink fieldCode="AU" term="%22Parry+CS%22">Parry CS</searchLink>; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.; MD/PhD Program, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Miller+SA%22">Miller SA</searchLink>; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.<br /><searchLink fieldCode="AU" term="%22Malhotra+S%22">Malhotra S</searchLink>; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.<br /><searchLink fieldCode="AU" term="%22Doyle+GA%22">Doyle GA</searchLink>; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.<br /><searchLink fieldCode="AU" term="%22Shimabenga+E%22">Shimabenga E</searchLink>; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.<br /><searchLink fieldCode="AU" term="%22Nurilloeva+M%22">Nurilloeva M</searchLink>; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.<br /><searchLink fieldCode="AU" term="%22Bondarenko+E%22">Bondarenko E</searchLink>; Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia PA.; Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia PA.<br /><searchLink fieldCode="AU" term="%22Andrianov+GV%22">Andrianov GV</searchLink>; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.<br /><searchLink fieldCode="AU" term="%22Childers+W%22">Childers W</searchLink>; Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Blass+BE%22">Blass BE</searchLink>; Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Makhov+PB%22">Makhov PB</searchLink>; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.<br /><searchLink fieldCode="AU" term="%22Whetstine+JR%22">Whetstine JR</searchLink>; Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia PA.; Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia PA.<br /><searchLink fieldCode="AU" term="%22Clapper+ML%22">Clapper ML</searchLink>; Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia PA.<br /><searchLink fieldCode="AU" term="%22Golemis+EA%22">Golemis EA</searchLink>; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.; Department of Cancer and Cellular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Karanicolas+J%22">Karanicolas J</searchLink>; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.; Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, PA.
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