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Machine learning cross-platform proteomic imputation enables protein quality scoring and replication of epidemiological associations.

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Title: Machine learning cross-platform proteomic imputation enables protein quality scoring and replication of epidemiological associations.
Authors: Li L; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA.; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA., Alaa A; Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA.; University of California, San Francisco, San Francisco, CA., Tan Y; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA., Demirel I; Massachusetts Institute of Technology, Cambridge, MA., Friedman S; ML4H, Broad Institute of Harvard and MIT, Cambridge, MA., Zha Q; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA., Tracy R; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Yu B; Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX., Ballantyne CM; Department of Medicine, Baylor College of Medicine, Houston, TX., Deo R; Division of Cardiovascular Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Dubin R; Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX., Tsai MY; Department of Laboratory Medicine & Pathology, University of Minnesota Medical School, Minneapolis, MN., Peloso GM; Department of Biostatistics, Boston University School of Public Health, Boston, MA., Brody J; Cardiovascular Health Research Unit, Department of Medicine & Deparment of Epidemiology, University of Washington, Seattle, WA., Austin T; Cardiovascular Health Research Unit, Department of Medicine & Deparment of Epidemiology, University of Washington, Seattle, WA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine & Deparment of Epidemiology, University of Washington, Seattle, WA., Nicholas J; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Tahir U; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA., Coresh J; Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA., Hornsby W; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA.; Heart and Vascular Institute, Mass General Brigham, Boston, MA., Chan A; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA., Rich SS; Department of Genome Sciences, University of Virginia, Charlottesville, VA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Ganz P; Division of Cardiology, Zuckerberg San Francisco General Hospital and Department of Medicine, University of California San Francisco, San Francisco, CA., Gerszten R; Heart and Vascular Institute, Mass General Brigham, Boston, MA., Philippakis A; Google Ventures, Cambridge, MA., Natarajan P; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA.; Heart and Vascular Institute, Mass General Brigham, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA., Yu Z; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA.; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 09. Date of Electronic Publication: 2026 May 09.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA.; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Alaa+A%22">Alaa A</searchLink>; Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA.; University of California, San Francisco, San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Tan+Y%22">Tan Y</searchLink>; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Demirel+I%22">Demirel I</searchLink>; Massachusetts Institute of Technology, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Friedman+S%22">Friedman S</searchLink>; ML4H, Broad Institute of Harvard and MIT, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Zha+Q%22">Zha Q</searchLink>; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Tracy+R%22">Tracy R</searchLink>; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT.<br /><searchLink fieldCode="AU" term="%22Taylor+KD%22">Taylor KD</searchLink>; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA.<br /><searchLink fieldCode="AU" term="%22Yu+B%22">Yu B</searchLink>; Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Ballantyne+CM%22">Ballantyne CM</searchLink>; Department of Medicine, Baylor College of Medicine, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Deo+R%22">Deo R</searchLink>; Division of Cardiovascular Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Dubin+R%22">Dubin R</searchLink>; Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX.<br /><searchLink fieldCode="AU" term="%22Tsai+MY%22">Tsai MY</searchLink>; Department of Laboratory Medicine & Pathology, University of Minnesota Medical School, Minneapolis, MN.<br /><searchLink fieldCode="AU" term="%22Peloso+GM%22">Peloso GM</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Brody+J%22">Brody J</searchLink>; Cardiovascular Health Research Unit, Department of Medicine & Deparment of Epidemiology, University of Washington, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Austin+T%22">Austin T</searchLink>; Cardiovascular Health Research Unit, Department of Medicine & Deparment of Epidemiology, University of Washington, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Psaty+BM%22">Psaty BM</searchLink>; Cardiovascular Health Research Unit, Department of Medicine & Deparment of Epidemiology, University of Washington, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Nicholas+J%22">Nicholas J</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC.<br /><searchLink fieldCode="AU" term="%22Raffield+LM%22">Raffield LM</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC.<br /><searchLink fieldCode="AU" term="%22Tahir+U%22">Tahir U</searchLink>; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Coresh+J%22">Coresh J</searchLink>; Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hornsby+W%22">Hornsby W</searchLink>; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA.; Heart and Vascular Institute, Mass General Brigham, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Chan+A%22">Chan A</searchLink>; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Rich+SS%22">Rich SS</searchLink>; Department of Genome Sciences, University of Virginia, Charlottesville, VA.<br /><searchLink fieldCode="AU" term="%22Rotter+JI%22">Rotter JI</searchLink>; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA.<br /><searchLink fieldCode="AU" term="%22Ganz+P%22">Ganz P</searchLink>; Division of Cardiology, Zuckerberg San Francisco General Hospital and Department of Medicine, University of California San Francisco, San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Gerszten+R%22">Gerszten R</searchLink>; Heart and Vascular Institute, Mass General Brigham, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Philippakis+A%22">Philippakis A</searchLink>; Google Ventures, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Natarajan+P%22">Natarajan P</searchLink>; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA.; Heart and Vascular Institute, Mass General Brigham, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Yu+Z%22">Yu Z</searchLink>; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA.; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.
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