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Organoid modeling of tumor-associated macrophages reveals phagocytosis checkpoint blockade-induced conversion to an immunosuppressive SPP1+ phenotype.

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Title: Organoid modeling of tumor-associated macrophages reveals phagocytosis checkpoint blockade-induced conversion to an immunosuppressive SPP1+ phenotype.
Authors: Nakano M, Heo L, Yang YP, Munoz LP, Liu Y, Zhao L, Park J, Tsekitsidou E, Francois A, Liu J, Trotman-Grant AC, Echeverri MFH, Rada CC, Tran E, Khokhar A, Yuki K, Bhattacharya A, Horn HT, Polak R, Yenwongfai LN, Li Y, Peach M, Nasajpour E, Pavlovitch-Bedzyk AJ, Chang ALS, Lim M, Petritsch CK, Gephart MH, Leppert JT, Nair RV, Davis MM, Bassik MC, Zhang M, Odegard J, Bates JG, Leung LLK, Majeti R, Kuo CJ
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 09. Date of Electronic Publication: 2026 May 09.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42146655
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Organoid modeling of tumor-associated macrophages reveals phagocytosis checkpoint blockade-induced conversion to an immunosuppressive SPP1+ phenotype.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 May 09. <i>Date of Electronic Publication: </i>2026 May 09.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.64898/2026.05.06.722767
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        Text: English
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              Text: 2026 May 09
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