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Structure-enabled enhancement of potency in a metronidazole-benznidazole hybrid: design, synthesis, and evaluation of antitrypanosomal activity of a benzylamide-linked 5-nitroimidazole.

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Title: Structure-enabled enhancement of potency in a metronidazole-benznidazole hybrid: design, synthesis, and evaluation of antitrypanosomal activity of a benzylamide-linked 5-nitroimidazole.
Authors: Velez ASMM; Department of Organic Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica, Brazil., Chaves OA; Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Science, University of Coimbra, Coimbra, Portugal.; Laboratory of Immunopharmacology, Center for Research, Innovation and Surveillance in COVID-19 and Health Emergencies (CPIV), Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil., Costa T; Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Science, University of Coimbra, Coimbra, Portugal., Serpa C; Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Science, University of Coimbra, Coimbra, Portugal., Borges JM; Departamento de Microbiologia e Imunologia Veterinária, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, Brazil., Freire-de-Lima CG; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Decote-Ricardo D; Departamento de Microbiologia e Imunologia Veterinária, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, Brazil., Lima MEF; Department of Organic Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica, Brazil.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 Apr 30; Vol. 17, pp. 1812023. Date of Electronic Publication: 2026 Apr 30 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Structure-enabled enhancement of potency in a metronidazole-benznidazole hybrid: design, synthesis, and evaluation of antitrypanosomal activity of a benzylamide-linked 5-nitroimidazole.
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  Data: <searchLink fieldCode="AU" term="%22Velez+ASMM%22">Velez ASMM</searchLink>; Department of Organic Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica, Brazil.<br /><searchLink fieldCode="AU" term="%22Chaves+OA%22">Chaves OA</searchLink>; Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Science, University of Coimbra, Coimbra, Portugal.; Laboratory of Immunopharmacology, Center for Research, Innovation and Surveillance in COVID-19 and Health Emergencies (CPIV), Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Costa+T%22">Costa T</searchLink>; Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Science, University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Serpa+C%22">Serpa C</searchLink>; Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Science, University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Borges+JM%22">Borges JM</searchLink>; Departamento de Microbiologia e Imunologia Veterinária, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, Brazil.<br /><searchLink fieldCode="AU" term="%22Freire-de-Lima+CG%22">Freire-de-Lima CG</searchLink>; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Decote-Ricardo+D%22">Decote-Ricardo D</searchLink>; Departamento de Microbiologia e Imunologia Veterinária, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, Brazil.<br /><searchLink fieldCode="AU" term="%22Lima+MEF%22">Lima MEF</searchLink>; Department of Organic Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica, Brazil.
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  Data: <searchLink fieldCode="JN" term="%22101548923%22">Frontiers in pharmacology</searchLink> [Front Pharmacol] 2026 Apr 30; Vol. 17, pp. 1812023. <i>Date of Electronic Publication: </i>2026 Apr 30 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Media]%22">Frontiers Media] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101548923 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1663-9812 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216639812%22">16639812 </searchLink><i>NLM ISO Abbreviation: </i>Front Pharmacol <i>Subsets: </i>PubMed not MEDLINE
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