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Arrayed dual-gRNA CRISPR screening platform for C9orf72 repeat expansion excision in patient iPSCs.

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Title: Arrayed dual-gRNA CRISPR screening platform for C9orf72 repeat expansion excision in patient iPSCs.
Authors: Arogundade OA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Lam KJK; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Brown KA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Jain T; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Issagholian-Lewin PO; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Huang C; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Rae-Hudson T; Innovative Genomics Institute, Berkeley, CA 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA., Briseno K; Innovative Genomics Institute, Berkeley, CA 94720, USA., Wyman SK; Innovative Genomics Institute, Berkeley, CA 94720, USA., Krishnappa N; Innovative Genomics Institute, Berkeley, CA 94720, USA., George CA; Innovative Genomics Institute, Berkeley, CA 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA., O'Dare K; The School of Medicine, Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff, Wales CF10 3AT, UK., Wilson RHC; The School of Medicine, Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff, Wales CF10 3AT, UK., van Eijk P; The School of Medicine, Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff, Wales CF10 3AT, UK.; Broken String Biosciences, Unit AB3-04, Level 3, BioData Innovation Centre, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1DR, UK., Reed SH; The School of Medicine, Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff, Wales CF10 3AT, UK.; Broken String Biosciences, Unit AB3-04, Level 3, BioData Innovation Centre, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1DR, UK., Giannikopoulos P; Innovative Genomics Institute, Berkeley, CA 94720, USA.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA., Clelland CD; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.; Innovative Genomics Institute, Berkeley, CA 94720, USA.; Memory & Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
Source: Molecular therapy. Advances [Mol Ther Adv] 2026 Apr 20; Vol. 34 (2), pp. 201741. Date of Electronic Publication: 2026 Apr 20 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Country of Publication: United States NLM ID: 9919257804006676 Publication Model: eCollection Cited Medium: Print ISSN: 3117-387X (Print) Linking ISSN: 3117387X NLM ISO Abbreviation: Mol Ther Adv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Arrayed dual-gRNA CRISPR screening platform for C9orf72 repeat expansion excision in patient iPSCs.
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  Data: <searchLink fieldCode="AU" term="%22Arogundade+OA%22">Arogundade OA</searchLink>; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Lam+KJK%22">Lam KJK</searchLink>; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Brown+KA%22">Brown KA</searchLink>; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Jain+T%22">Jain T</searchLink>; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Issagholian-Lewin+PO%22">Issagholian-Lewin PO</searchLink>; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Huang+C%22">Huang C</searchLink>; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Rae-Hudson+T%22">Rae-Hudson T</searchLink>; Innovative Genomics Institute, Berkeley, CA 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.<br /><searchLink fieldCode="AU" term="%22Briseno+K%22">Briseno K</searchLink>; Innovative Genomics Institute, Berkeley, CA 94720, USA.<br /><searchLink fieldCode="AU" term="%22Wyman+SK%22">Wyman SK</searchLink>; Innovative Genomics Institute, Berkeley, CA 94720, USA.<br /><searchLink fieldCode="AU" term="%22Krishnappa+N%22">Krishnappa N</searchLink>; Innovative Genomics Institute, Berkeley, CA 94720, USA.<br /><searchLink fieldCode="AU" term="%22George+CA%22">George CA</searchLink>; Innovative Genomics Institute, Berkeley, CA 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.<br /><searchLink fieldCode="AU" term="%22O'Dare+K%22">O'Dare K</searchLink>; The School of Medicine, Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff, Wales CF10 3AT, UK.<br /><searchLink fieldCode="AU" term="%22Wilson+RHC%22">Wilson RHC</searchLink>; The School of Medicine, Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff, Wales CF10 3AT, UK.<br /><searchLink fieldCode="AU" term="%22van+Eijk+P%22">van Eijk P</searchLink>; The School of Medicine, Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff, Wales CF10 3AT, UK.; Broken String Biosciences, Unit AB3-04, Level 3, BioData Innovation Centre, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1DR, UK.<br /><searchLink fieldCode="AU" term="%22Reed+SH%22">Reed SH</searchLink>; The School of Medicine, Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff, Wales CF10 3AT, UK.; Broken String Biosciences, Unit AB3-04, Level 3, BioData Innovation Centre, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1DR, UK.<br /><searchLink fieldCode="AU" term="%22Giannikopoulos+P%22">Giannikopoulos P</searchLink>; Innovative Genomics Institute, Berkeley, CA 94720, USA.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Clelland+CD%22">Clelland CD</searchLink>; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.; Innovative Genomics Institute, Berkeley, CA 94720, USA.; Memory & Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
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  Data: <searchLink fieldCode="JN" term="%229919257804006676%22">Molecular therapy. Advances</searchLink> [Mol Ther Adv] 2026 Apr 20; Vol. 34 (2), pp. 201741. <i>Date of Electronic Publication: </i>2026 Apr 20 (<i>Print Publication: </i>2026).
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