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Logistical Challenges in Platform Randomized Trials - Operational Realities That Curb the Promise of Efficiency.

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Title: Logistical Challenges in Platform Randomized Trials - Operational Realities That Curb the Promise of Efficiency.
Authors: Thorlund K; Department Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital Rigshospitalet, Copenhagen Ø, Denmark., Park JJH; Department Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; Core Clinical Sciences Inc., Vancouver, BC, Canada., Wise MP; Adult Critical Care, University Hospital of Wales, Cardiff, UK., Doleman B; School of Medicine, University of Nottingham, Nottingham, UK., Petersen JJ; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital Rigshospitalet, Copenhagen Ø, Denmark., Lange T; Department of Public Health, Copenhagen University, Copenhagen, Denmark., Mathiesen O; Centre for Anaesthesiological Research, Department Anaesthesiology, Zealand University Hospital, Koege, Denmark.; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark., Skrifvars MB; Department of Anaesthesiology and Intensive Care Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Saxena M; Faculty of Medicine, UNSW, Sydney, Australia., Nielsen N; Department of Clinical Sciences Lund, Lund University, Lund, Sweden., Mills EJ; Department Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada., Grand J; Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Jakobsen JC; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital Rigshospitalet, Copenhagen Ø, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Source: Clinical epidemiology [Clin Epidemiol] 2026 May 11; Vol. 18, pp. 580997. Date of Electronic Publication: 2026 May 11 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Dove Medical Press Country of Publication: New Zealand NLM ID: 101531700 Publication Model: eCollection Cited Medium: Print ISSN: 1179-1349 (Print) Linking ISSN: 11791349 NLM ISO Abbreviation: Clin Epidemiol Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Thorlund+K%22">Thorlund K</searchLink>; Department Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital Rigshospitalet, Copenhagen Ø, Denmark.<br /><searchLink fieldCode="AU" term="%22Park+JJH%22">Park JJH</searchLink>; Department Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; Core Clinical Sciences Inc., Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Wise+MP%22">Wise MP</searchLink>; Adult Critical Care, University Hospital of Wales, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Doleman+B%22">Doleman B</searchLink>; School of Medicine, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Petersen+JJ%22">Petersen JJ</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital Rigshospitalet, Copenhagen Ø, Denmark.<br /><searchLink fieldCode="AU" term="%22Lange+T%22">Lange T</searchLink>; Department of Public Health, Copenhagen University, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Mathiesen+O%22">Mathiesen O</searchLink>; Centre for Anaesthesiological Research, Department Anaesthesiology, Zealand University Hospital, Koege, Denmark.; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Skrifvars+MB%22">Skrifvars MB</searchLink>; Department of Anaesthesiology and Intensive Care Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Saxena+M%22">Saxena M</searchLink>; Faculty of Medicine, UNSW, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Nielsen+N%22">Nielsen N</searchLink>; Department of Clinical Sciences Lund, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Mills+EJ%22">Mills EJ</searchLink>; Department Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Grand+J%22">Grand J</searchLink>; Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Jakobsen+JC%22">Jakobsen JC</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital Rigshospitalet, Copenhagen Ø, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
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  Data: <searchLink fieldCode="JN" term="%22101531700%22">Clinical epidemiology</searchLink> [Clin Epidemiol] 2026 May 11; Vol. 18, pp. 580997. <i>Date of Electronic Publication: </i>2026 May 11 (<i>Print Publication: </i>2026).
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