GLP1-E2 therapy delays autoimmune diabetes in late-stage prediabetic NOD mice and potentiates low-dose anti-CD3 therapy for enhanced disease protection.
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| Title: | GLP1-E2 therapy delays autoimmune diabetes in late-stage prediabetic NOD mice and potentiates low-dose anti-CD3 therapy for enhanced disease protection. |
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| Authors: | Degroote L; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium., Chrzanowski J; Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland., Lemaitre P; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium., Wouters A; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium., Bourgeois S; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Van Mulders A; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Pierreux J; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Coenen S; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Willems L; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Leuckx G; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Viaene M; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium., Packbier M; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium., Douros JD; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA., Yang B; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA., Heremans Y; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Mathieu C; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium., Staels W; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; Division of Pediatric Endocrinology, Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Gysemans C; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium. conny.gysemans@kuleuven.be., De Leu N; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium. nico.de.leu@vub.be.; Department of Diabetology and Endocrinology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium. nico.de.leu@vub.be.; Department of Diabetology and Endocrinology, AZORG, Aalst, Belgium. nico.de.leu@vub.be. |
| Source: | Diabetologia [Diabetologia] 2026 Aug; Vol. 69 (8), pp. 2307-2322. Date of Electronic Publication: 2026 May 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42149241 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: GLP1-E2 therapy delays autoimmune diabetes in late-stage prediabetic NOD mice and potentiates low-dose anti-CD3 therapy for enhanced disease protection. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Degroote+L%22">Degroote L</searchLink>; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Chrzanowski+J%22">Chrzanowski J</searchLink>; Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland.<br /><searchLink fieldCode="AU" term="%22Lemaitre+P%22">Lemaitre P</searchLink>; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Wouters+A%22">Wouters A</searchLink>; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Bourgeois+S%22">Bourgeois S</searchLink>; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+Mulders+A%22">Van Mulders A</searchLink>; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Pierreux+J%22">Pierreux J</searchLink>; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Coenen+S%22">Coenen S</searchLink>; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Willems+L%22">Willems L</searchLink>; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Leuckx+G%22">Leuckx G</searchLink>; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Viaene+M%22">Viaene M</searchLink>; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Packbier+M%22">Packbier M</searchLink>; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Douros+JD%22">Douros JD</searchLink>; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Yang+B%22">Yang B</searchLink>; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Heremans+Y%22">Heremans Y</searchLink>; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Mathieu+C%22">Mathieu C</searchLink>; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Staels+W%22">Staels W</searchLink>; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; Division of Pediatric Endocrinology, Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Gysemans+C%22">Gysemans C</searchLink>; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium. conny.gysemans@kuleuven.be.<br /><searchLink fieldCode="AU" term="%22De+Leu+N%22">De Leu N</searchLink>; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium. nico.de.leu@vub.be.; Department of Diabetology and Endocrinology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium. nico.de.leu@vub.be.; Department of Diabetology and Endocrinology, AZORG, Aalst, Belgium. nico.de.leu@vub.be. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220006777%22">Diabetologia</searchLink> [Diabetologia] 2026 Aug; Vol. 69 (8), pp. 2307-2322. <i>Date of Electronic Publication: </i>2026 May 18. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0006777 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0428 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220012186X%22">0012186X </searchLink><i>NLM ISO Abbreviation: </i>Diabetologia <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42149241 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00125-026-06750-1 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 2307 Titles: – TitleFull: GLP1-E2 therapy delays autoimmune diabetes in late-stage prediabetic NOD mice and potentiates low-dose anti-CD3 therapy for enhanced disease protection. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Degroote L – PersonEntity: Name: NameFull: Chrzanowski J – PersonEntity: Name: NameFull: Lemaitre P – PersonEntity: Name: NameFull: Wouters A – PersonEntity: Name: NameFull: Bourgeois S – PersonEntity: Name: NameFull: Van Mulders A – PersonEntity: Name: NameFull: Pierreux J – PersonEntity: Name: NameFull: Coenen S – PersonEntity: Name: NameFull: Willems L – PersonEntity: Name: NameFull: Leuckx G – PersonEntity: Name: NameFull: Viaene M – PersonEntity: Name: NameFull: Packbier M – PersonEntity: Name: NameFull: Douros JD – PersonEntity: Name: NameFull: Yang B – PersonEntity: Name: NameFull: Heremans Y – PersonEntity: Name: NameFull: Mathieu C – PersonEntity: Name: NameFull: Staels W – PersonEntity: Name: NameFull: Gysemans C – PersonEntity: Name: NameFull: De Leu N IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: 2026 Aug Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1432-0428 Numbering: – Type: volume Value: 69 – Type: issue Value: 8 Titles: – TitleFull: Diabetologia Type: main |
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