GLP1-E2 therapy delays autoimmune diabetes in late-stage prediabetic NOD mice and potentiates low-dose anti-CD3 therapy for enhanced disease protection.
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| Title: | GLP1-E2 therapy delays autoimmune diabetes in late-stage prediabetic NOD mice and potentiates low-dose anti-CD3 therapy for enhanced disease protection. |
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| Authors: | Degroote L; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium., Chrzanowski J; Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland., Lemaitre P; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium., Wouters A; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium., Bourgeois S; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Van Mulders A; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Pierreux J; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Coenen S; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Willems L; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Leuckx G; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Viaene M; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium., Packbier M; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium., Douros JD; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA., Yang B; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA., Heremans Y; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Mathieu C; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium., Staels W; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; Division of Pediatric Endocrinology, Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Gysemans C; Leuven Diabetes Lab, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium. conny.gysemans@kuleuven.be., De Leu N; Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium. nico.de.leu@vub.be.; Department of Diabetology and Endocrinology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium. nico.de.leu@vub.be.; Department of Diabetology and Endocrinology, AZORG, Aalst, Belgium. nico.de.leu@vub.be. |
| Source: | Diabetologia [Diabetologia] 2026 Aug; Vol. 69 (8), pp. 2307-2322. Date of Electronic Publication: 2026 May 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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