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A human cardiomyocyte screen identifies optimized lipid nanoparticles for in vivo cardiac gene editing.

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Title: A human cardiomyocyte screen identifies optimized lipid nanoparticles for in vivo cardiac gene editing.
Authors: Sun Y; Department of Biomedical Engineering, Simmons Comprehensive Cancer Center, Program in Genetic Drug Engineering, The University of Texas Southwestern Medical Center, Dallas, TX 75390.; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390., Pien YC; Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390., Xiao Y; Department of Biomedical Engineering, Simmons Comprehensive Cancer Center, Program in Genetic Drug Engineering, The University of Texas Southwestern Medical Center, Dallas, TX 75390.; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390., Tan W; Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390., Sanchez-Ortiz E; Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390., Durbacz MZ; Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390., Chen Z; Department of Biomedical Engineering, Simmons Comprehensive Cancer Center, Program in Genetic Drug Engineering, The University of Texas Southwestern Medical Center, Dallas, TX 75390.; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390., McAnally JR; Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390., Zhang Y; Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390., Li H; Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390., Chai AC; Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390., Chemello F; Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390., Zhang F; Department of Biomedical Engineering, Simmons Comprehensive Cancer Center, Program in Genetic Drug Engineering, The University of Texas Southwestern Medical Center, Dallas, TX 75390.; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390., Lee SM; Department of Biomedical Engineering, Simmons Comprehensive Cancer Center, Program in Genetic Drug Engineering, The University of Texas Southwestern Medical Center, Dallas, TX 75390.; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390., Patel P; Department of Biomedical Engineering, Simmons Comprehensive Cancer Center, Program in Genetic Drug Engineering, The University of Texas Southwestern Medical Center, Dallas, TX 75390.; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390., Ramirez DM; Department of Neurology, The University of Texas Southwestern Medical Center, Dallas, TX 75390., Chatterjee S; Department of Biomedical Engineering, Simmons Comprehensive Cancer Center, Program in Genetic Drug Engineering, The University of Texas Southwestern Medical Center, Dallas, TX 75390.; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390., Liu N; Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390., Olson EN; Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390., Siegwart DJ; Department of Biomedical Engineering, Simmons Comprehensive Cancer Center, Program in Genetic Drug Engineering, The University of Texas Southwestern Medical Center, Dallas, TX 75390.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 May 26; Vol. 123 (21), pp. e2528477123. Date of Electronic Publication: 2026 May 18.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 May 26; Vol. 123 (21), pp. e2528477123. <i>Date of Electronic Publication: </i>2026 May 18.
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