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Environmental cadmium drives placental senescence and fetal growth restriction via activating CLPP-dependent mitochondrial stress.

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Title: Environmental cadmium drives placental senescence and fetal growth restriction via activating CLPP-dependent mitochondrial stress.
Authors: Pan R; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China., Zhang J; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China., Wu LL; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China., Sun CF; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China., Zhang XX; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China., Wu YX; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China., Yin XA; The Fourth Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei 230000, China., Luo YX; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China., Liu ST; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China., Bao ZJ; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China., Chang W; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China., Zhao LL; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China., Xu DX; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China., Feng YL; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Center of Prenatal Diagnosis, Wuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Wuxi 214000, China. Electronic address: 9862023235@jiangnan.edu.cn., Wang H; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China; Department of Rehabilitation Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China. Electronic address: wanghuadev@ahmu.edu.cn., Zhu HL; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China; Department of Rehabilitation Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China. Electronic address: zhuhualongdev@ahmu.edu.cn.
Source: Journal of hazardous materials [J Hazard Mater] 2026 Jul 01; Vol. 512, pp. 142400. Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9422688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3336 (Electronic) Linking ISSN: 03043894 NLM ISO Abbreviation: J Hazard Mater Subsets: MEDLINE
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  Data: Environmental cadmium drives placental senescence and fetal growth restriction via activating CLPP-dependent mitochondrial stress.
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  Data: <searchLink fieldCode="AU" term="%22Pan+R%22">Pan R</searchLink>; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China.<br /><searchLink fieldCode="AU" term="%22Wu+LL%22">Wu LL</searchLink>; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China.<br /><searchLink fieldCode="AU" term="%22Sun+CF%22">Sun CF</searchLink>; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China.<br /><searchLink fieldCode="AU" term="%22Zhang+XX%22">Zhang XX</searchLink>; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China.<br /><searchLink fieldCode="AU" term="%22Wu+YX%22">Wu YX</searchLink>; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China.<br /><searchLink fieldCode="AU" term="%22Yin+XA%22">Yin XA</searchLink>; The Fourth Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei 230000, China.<br /><searchLink fieldCode="AU" term="%22Luo+YX%22">Luo YX</searchLink>; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China.<br /><searchLink fieldCode="AU" term="%22Liu+ST%22">Liu ST</searchLink>; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China.<br /><searchLink fieldCode="AU" term="%22Bao+ZJ%22">Bao ZJ</searchLink>; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China.<br /><searchLink fieldCode="AU" term="%22Chang+W%22">Chang W</searchLink>; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China.<br /><searchLink fieldCode="AU" term="%22Zhao+LL%22">Zhao LL</searchLink>; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China.<br /><searchLink fieldCode="AU" term="%22Xu+DX%22">Xu DX</searchLink>; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China.<br /><searchLink fieldCode="AU" term="%22Feng+YL%22">Feng YL</searchLink>; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Center of Prenatal Diagnosis, Wuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Wuxi 214000, China. Electronic address: 9862023235@jiangnan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China; Department of Rehabilitation Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China. Electronic address: wanghuadev@ahmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhu+HL%22">Zhu HL</searchLink>; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230000, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230000, China; Department of Rehabilitation Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China. Electronic address: zhuhualongdev@ahmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229422688%22">Journal of hazardous materials</searchLink> [J Hazard Mater] 2026 Jul 01; Vol. 512, pp. 142400. <i>Date of Electronic Publication: </i>2026 May 15.
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        Value: 10.1016/j.jhazmat.2026.142400
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      – Code: eng
        Text: English
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        StartPage: 142400
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      – TitleFull: Environmental cadmium drives placental senescence and fetal growth restriction via activating CLPP-dependent mitochondrial stress.
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              Text: 2026 Jul 01
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