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Scalable and sustainable manufacturing of functional DNA nanoassemblies via self-folding circular single-stranded DNA.

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Title: Scalable and sustainable manufacturing of functional DNA nanoassemblies via self-folding circular single-stranded DNA.
Authors: Zhai T; State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, and the International Peace Maternity and Child Health Hospital, School of Medicine, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.; Department of Multidisciplinary Consultant Center, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200001, China., Liu S; State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China., Lei D; State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, and the International Peace Maternity and Child Health Hospital, School of Medicine, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China., Song T; The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, the Key Laboratory of Chemical Biology of Fujian Province, Department of Chemical Biology, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University, Fujian, 361005, China., Tam RC; State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China., Chen M; The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, the Key Laboratory of Chemical Biology of Fujian Province, Department of Chemical Biology, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University, Fujian, 361005, China., Zhang J; State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, and the International Peace Maternity and Child Health Hospital, School of Medicine, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China., Qian J; State Key Laboratory of Bioreactor Engineering, East China University of Science & Technology, Shanghai, 200237, China., Fan C; State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, and the International Peace Maternity and Child Health Hospital, School of Medicine, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.; SJTU Asia-Pacific Graduate Institute (SJTU-APGI), 1 Create Way, #14-01 CREATE Tower, Singapore, 138602, Singapore.; Xiangfu Laboratory, Jiashan, 314102, China., Chen H; State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China. hlchen@hku.hk., Song Y; The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, the Key Laboratory of Chemical Biology of Fujian Province, Department of Chemical Biology, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University, Fujian, 361005, China. ylsong@xmu.edu.cn., Gu H; State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, and the International Peace Maternity and Child Health Hospital, School of Medicine, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China. hongzhou.gu@sjtu.edu.cn.; Department of Multidisciplinary Consultant Center, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200001, China. hongzhou.gu@sjtu.edu.cn.; SJTU Asia-Pacific Graduate Institute (SJTU-APGI), 1 Create Way, #14-01 CREATE Tower, Singapore, 138602, Singapore. hongzhou.gu@sjtu.edu.cn.; Xiangfu Laboratory, Jiashan, 314102, China. hongzhou.gu@sjtu.edu.cn.
Source: Nature communications [Nat Commun] 2026 May 18; Vol. 17 (1). Date of Electronic Publication: 2026 May 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Scalable and sustainable manufacturing of functional DNA nanoassemblies via self-folding circular single-stranded DNA.
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  Data: <searchLink fieldCode="AU" term="%22Zhai+T%22">Zhai T</searchLink>; State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, and the International Peace Maternity and Child Health Hospital, School of Medicine, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.; Department of Multidisciplinary Consultant Center, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200001, China.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Lei+D%22">Lei D</searchLink>; State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, and the International Peace Maternity and Child Health Hospital, School of Medicine, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.<br /><searchLink fieldCode="AU" term="%22Song+T%22">Song T</searchLink>; The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, the Key Laboratory of Chemical Biology of Fujian Province, Department of Chemical Biology, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University, Fujian, 361005, China.<br /><searchLink fieldCode="AU" term="%22Tam+RC%22">Tam RC</searchLink>; State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Chen+M%22">Chen M</searchLink>; The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, the Key Laboratory of Chemical Biology of Fujian Province, Department of Chemical Biology, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University, Fujian, 361005, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, and the International Peace Maternity and Child Health Hospital, School of Medicine, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.<br /><searchLink fieldCode="AU" term="%22Qian+J%22">Qian J</searchLink>; State Key Laboratory of Bioreactor Engineering, East China University of Science & Technology, Shanghai, 200237, China.<br /><searchLink fieldCode="AU" term="%22Fan+C%22">Fan C</searchLink>; State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, and the International Peace Maternity and Child Health Hospital, School of Medicine, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.; SJTU Asia-Pacific Graduate Institute (SJTU-APGI), 1 Create Way, #14-01 CREATE Tower, Singapore, 138602, Singapore.; Xiangfu Laboratory, Jiashan, 314102, China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China. hlchen@hku.hk.<br /><searchLink fieldCode="AU" term="%22Song+Y%22">Song Y</searchLink>; The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, the Key Laboratory of Chemical Biology of Fujian Province, Department of Chemical Biology, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University, Fujian, 361005, China. ylsong@xmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Gu+H%22">Gu H</searchLink>; State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, and the International Peace Maternity and Child Health Hospital, School of Medicine, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China. hongzhou.gu@sjtu.edu.cn.; Department of Multidisciplinary Consultant Center, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200001, China. hongzhou.gu@sjtu.edu.cn.; SJTU Asia-Pacific Graduate Institute (SJTU-APGI), 1 Create Way, #14-01 CREATE Tower, Singapore, 138602, Singapore. hongzhou.gu@sjtu.edu.cn.; Xiangfu Laboratory, Jiashan, 314102, China. hongzhou.gu@sjtu.edu.cn.
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