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Integrated multi-omics identifies distinct macrophage alterations during progression of metabolic dysfunction-associated steatohepatitis.

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Title: Integrated multi-omics identifies distinct macrophage alterations during progression of metabolic dysfunction-associated steatohepatitis.
Authors: Boesch M; Laboratory of Liver Immunology, Leuven Center of Molecular Liver Sciences, Hepatology Research Unit, CHROMETA Department, KU Leuven, Leuven, Belgium.; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium.; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium.; Laboratory of Reproductive Genomics, Department of Human Genetics, KU Leuven, Leuven, Belgium., Anak S; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium., El Abyad D; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium., Ostyn T; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium., Antoranz A; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium.; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium., My Van T; Bruker Spatial Biology, Seattle, WA, USA., Newhouse D; Bruker Spatial Biology, Seattle, WA, USA., Myers C; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden., Van Melkebeke L; Laboratory of Liver Immunology, Leuven Center of Molecular Liver Sciences, Hepatology Research Unit, CHROMETA Department, KU Leuven, Leuven, Belgium.; Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium., Palmer J; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Saffarzadeh N; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden., Chui JS; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium.; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium., Feio-Azevedo R; Laboratory of Liver Immunology, Leuven Center of Molecular Liver Sciences, Hepatology Research Unit, CHROMETA Department, KU Leuven, Leuven, Belgium., Smets L; Laboratory of Liver Immunology, Leuven Center of Molecular Liver Sciences, Hepatology Research Unit, CHROMETA Department, KU Leuven, Leuven, Belgium., Shankar G; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium.; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium., Dubroja Lakić N; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium.; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium., Calvo PL; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium.; Laboratory of Reproductive Genomics, Department of Human Genetics, KU Leuven, Leuven, Belgium., Voet T; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium.; Laboratory of Reproductive Genomics, Department of Human Genetics, KU Leuven, Leuven, Belgium., Clark J; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Cockell S; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Lannoo M; Department of Abdominal Surgery, UZ Leuven, Leuven, Belgium., Deleus E; Department of Abdominal Surgery, UZ Leuven, Leuven, Belgium., Jaekers J; Department of Abdominal Surgery, UZ Leuven, Leuven, Belgium., Topal H; Department of Abdominal Surgery, UZ Leuven, Leuven, Belgium., Topal B; Department of Abdominal Surgery, UZ Leuven, Leuven, Belgium., Schneider KM; Medical Clinic III, Gastroenterology, Metabolic diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.; Department of Medicine 1, University Hospital Carl Gustav Carus Dresden, TUD Dresden University of Technology, Dresden, Germany.; Else Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.; Center for Regenerative Therapies Dresden (CRTD), TUD Dresden University of Technology, Dresden, Germany., Vacca M; Roger Williams Institute of Liver Studies, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, Foundation for Liver Research and King's College Hospital, London, UK.; Clinica Medica 'C. Frugoni' and Department of Interdisciplinary Medicine, Aldo Moro University of Bari, Bari, Italy., Allison M; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge NIHR Biomedical Research Centre, Cambridge, UK., Ekstedt M; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden., Boursier J; Hepatology Department, Angers University Hospital, Angers, France., Bugianesi E; Department of Medical Sciences, Division of Gastro-Hepatology, A.O. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy., Ratziu V; Assistance Publique-Hôpitaux de Paris, Hôpital Pitié Salpêtrière, Sorbonne University, Institute of Cardiometabolism and Nutrition (ICAN), Paris, France., De Smet F; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium.; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium., Boeckx B; Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.; VIB Center for Cancer Biology, Leuven, Belgium., Daly AK; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Schattenberg JM; Department of Internal Medicine II, Saarland University Medical Center, Homburg, Germany., Verbeek J; Laboratory of Liver Immunology, Leuven Center of Molecular Liver Sciences, Hepatology Research Unit, CHROMETA Department, KU Leuven, Leuven, Belgium.; Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium., Bosisio F; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium.; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium., Lambrechts D; Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.; VIB Center for Cancer Biology, Leuven, Belgium., Roskams T; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium., Schneider CV; Medical Clinic III, Gastroenterology, Metabolic diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany., Francque S; Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium.; Translational Research in Inflammation and Immunology (TWI2N), Laboratory of Experimental Medicine and Paediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium., Korf H; Laboratory of Liver Immunology, Leuven Center of Molecular Liver Sciences, Hepatology Research Unit, CHROMETA Department, KU Leuven, Leuven, Belgium., Härtlova A; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.; Institute of Medical Microbiology, Medical centre, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Tiniakos D; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Department of Pathology, Aretaieion Hospital, Medical School, National & Kapodistrian University of Athens, Athens, Greece., Anstee QM; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. quentin.anstee@newcastle.ac.uk.; Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK. quentin.anstee@newcastle.ac.uk., van der Merwe S; Laboratory of Liver Immunology, Leuven Center of Molecular Liver Sciences, Hepatology Research Unit, CHROMETA Department, KU Leuven, Leuven, Belgium. schalk.vandermerwe@uzleuven.be.; Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium. schalk.vandermerwe@uzleuven.be., Govaere O; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium. olivier.govaere@kuleuven.be.; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium. olivier.govaere@kuleuven.be.; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. olivier.govaere@kuleuven.be.
Source: Nature genetics [Nat Genet] 2026 Jun; Vol. 58 (6), pp. 1295-1307. Date of Electronic Publication: 2026 May 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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  Data: Integrated multi-omics identifies distinct macrophage alterations during progression of metabolic dysfunction-associated steatohepatitis.
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Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Antoranz+A%22">Antoranz A</searchLink>; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium.; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22My+Van+T%22">My Van T</searchLink>; Bruker Spatial Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Newhouse+D%22">Newhouse D</searchLink>; Bruker Spatial Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Myers+C%22">Myers C</searchLink>; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Van+Melkebeke+L%22">Van Melkebeke L</searchLink>; Laboratory of Liver Immunology, Leuven Center of Molecular Liver Sciences, Hepatology Research Unit, CHROMETA Department, KU Leuven, Leuven, Belgium.; 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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2026 Jun; Vol. 58 (6), pp. 1295-1307. <i>Date of Electronic Publication: </i>2026 May 18.
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            NameFull: Allison M
      – PersonEntity:
          Name:
            NameFull: Ekstedt M
      – PersonEntity:
          Name:
            NameFull: Boursier J
      – PersonEntity:
          Name:
            NameFull: Bugianesi E
      – PersonEntity:
          Name:
            NameFull: Ratziu V
      – PersonEntity:
          Name:
            NameFull: De Smet F
      – PersonEntity:
          Name:
            NameFull: Boeckx B
      – PersonEntity:
          Name:
            NameFull: Daly AK
      – PersonEntity:
          Name:
            NameFull: Schattenberg JM
      – PersonEntity:
          Name:
            NameFull: Verbeek J
      – PersonEntity:
          Name:
            NameFull: Bosisio F
      – PersonEntity:
          Name:
            NameFull: Lambrechts D
      – PersonEntity:
          Name:
            NameFull: Roskams T
      – PersonEntity:
          Name:
            NameFull: Schneider CV
      – PersonEntity:
          Name:
            NameFull: Francque S
      – PersonEntity:
          Name:
            NameFull: Korf H
      – PersonEntity:
          Name:
            NameFull: Härtlova A
      – PersonEntity:
          Name:
            NameFull: Tiniakos D
      – PersonEntity:
          Name:
            NameFull: Anstee QM
      – PersonEntity:
          Name:
            NameFull: van der Merwe S
      – PersonEntity:
          Name:
            NameFull: Govaere O
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1546-1718
          Numbering:
            – Type: volume
              Value: 58
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Nature genetics
              Type: main
ResultId 1