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Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation.

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Title: Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation.
Authors: Kerndl M; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria., Musiejovsky L; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria., Komljenovic A; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD), Vienna, Austria., Lam HS; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD), Vienna, Austria., Vogel A; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.; LoopLab Bio, Vienna, Austria., Bausbacher T; Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Technische Hochschule Mannheim, Mannheim, Germany.; Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Riedl CJ; Divsion of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria.; Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna, Austria., Sango R; Center for Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical University of Vienna, Vienna, Austria.; Center for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.; Doctoral School in Microbiology and Environmental Science, University of Vienna, Vienna, Austria.; SFB Immunometabolism, Medical University of Vienna, Vienna, Austria., Matejovicova L; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD), Vienna, Austria., Dobrijevic A; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD), Vienna, Austria.; SFB Immunometabolism, Medical University of Vienna, Vienna, Austria., Oberbichler L; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Institute of Experimental Immunology, University of Zürich, Zurich, Switzerland., Hofmann M; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria., Kieler M; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria., Quemada Garrido L; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria., Perko Budja LV; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria., Brunner JS; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.; Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Cairns JL; Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Technische Hochschule Mannheim, Mannheim, Germany.; Medical Faculty, Heidelberg University, Heidelberg, Germany., Cheng P; Bio Cancer Treatment International, Hong Kong, China., Kitt K; Department for Cancer Immunology and Immune Modulation, Boehringer Ingelheim Pharma, Biberach, Germany., Isaguirre C; Mass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, USA., Köcher T; Vienna Biocenter Core Facilities, Vienna, Austria., Klavins K; Institute of Biomaterials and Bioengineering, Faculty of Natural Sciences and Technology, Riga Technical University, Riga, Latvia., Rattei T; Center for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.; SFB Immunometabolism, Medical University of Vienna, Vienna, Austria., Hametner S; Divsion of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria.; Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna, Austria., Blüml S; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Hopf C; Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Technische Hochschule Mannheim, Mannheim, Germany.; Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Medical Faculty, Heidelberg University, Heidelberg, Germany., Sheldon RD; Mass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, USA., Sharif O; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria. omar.sharif@meduniwien.ac.at.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD), Vienna, Austria. omar.sharif@meduniwien.ac.at.; SFB Immunometabolism, Medical University of Vienna, Vienna, Austria. omar.sharif@meduniwien.ac.at., Schabbauer G; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria. gernot.schabbauer@meduniwien.ac.at.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria. gernot.schabbauer@meduniwien.ac.at.; SFB Immunometabolism, Medical University of Vienna, Vienna, Austria. gernot.schabbauer@meduniwien.ac.at.
Source: Nature immunology [Nat Immunol] 2026 Jul; Vol. 27 (7), pp. 1418-1432. Date of Electronic Publication: 2026 May 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD), Vienna, Austria.; SFB Immunometabolism, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Oberbichler+L%22">Oberbichler L</searchLink>; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Institute of Experimental Immunology, University of Zürich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hofmann+M%22">Hofmann M</searchLink>; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Kieler+M%22">Kieler M</searchLink>; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Quemada+Garrido+L%22">Quemada Garrido L</searchLink>; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Perko+Budja+LV%22">Perko Budja LV</searchLink>; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Brunner+JS%22">Brunner JS</searchLink>; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.; Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cairns+JL%22">Cairns JL</searchLink>; Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Technische Hochschule Mannheim, Mannheim, Germany.; Medical Faculty, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Cheng+P%22">Cheng P</searchLink>; Bio Cancer Treatment International, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Kitt+K%22">Kitt K</searchLink>; Department for Cancer Immunology and Immune Modulation, Boehringer Ingelheim Pharma, Biberach, Germany.<br /><searchLink fieldCode="AU" term="%22Isaguirre+C%22">Isaguirre C</searchLink>; Mass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, USA.<br /><searchLink fieldCode="AU" term="%22Köcher+T%22">Köcher T</searchLink>; Vienna Biocenter Core Facilities, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Klavins+K%22">Klavins K</searchLink>; 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Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Technische Hochschule Mannheim, Mannheim, Germany.; Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Medical Faculty, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sheldon+RD%22">Sheldon RD</searchLink>; Mass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, USA.<br /><searchLink fieldCode="AU" term="%22Sharif+O%22">Sharif O</searchLink>; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria. omar.sharif@meduniwien.ac.at.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD), Vienna, Austria. omar.sharif@meduniwien.ac.at.; SFB Immunometabolism, Medical University of Vienna, Vienna, Austria. omar.sharif@meduniwien.ac.at.<br /><searchLink fieldCode="AU" term="%22Schabbauer+G%22">Schabbauer G</searchLink>; Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria. gernot.schabbauer@meduniwien.ac.at.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria. gernot.schabbauer@meduniwien.ac.at.; SFB Immunometabolism, Medical University of Vienna, Vienna, Austria. gernot.schabbauer@meduniwien.ac.at.
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