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Spatial proteomic analysis in human Alzheimer's disease brains enables identification of microenvironment-dependent microglial cell states.

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Title: Spatial proteomic analysis in human Alzheimer's disease brains enables identification of microenvironment-dependent microglial cell states.
Authors: Sanchez-Molina P; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA., Rosmus DD; Institute of Anatomy, Leipzig University, Leipzig, Germany.; Cellular Neuroanatomy, Chair of Anatomy and Cell Biology, Institute of Theoretical Medicine, University of Augsburg, Augsburg, Germany.; Department of Neurology, Leipzig University Medical Center, Leipzig, Germany., Brownell D; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA., Meral M; ariadne.ai AG, Lucerne, Switzerland., Gohlich C; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA., Pratapa A; Akoya Biosciences, Marlborough, MA, USA., Peymanfar Y; Akoya Biosciences, Marlborough, MA, USA., Whitley A; Akoya Biosciences, Marlborough, MA, USA., Hou Y; Akoya Biosciences, Marlborough, MA, USA., Nikulina N; Akoya Biosciences, Marlborough, MA, USA., Bogachuk A; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA., Bouchard EL; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA., Chiot A; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA., Kuhrt H; Institute of Anatomy, Leipzig University, Leipzig, Germany., Wieghofer P; Institute of Anatomy, Leipzig University, Leipzig, Germany.; Cellular Neuroanatomy, Chair of Anatomy and Cell Biology, Institute of Theoretical Medicine, University of Augsburg, Augsburg, Germany., Woltjer R; Department of Pathology, Oregon Health and Science University, Portland, OR, USA., Svara F; ariadne.ai AG, Lucerne, Switzerland., Braubach O; Akoya Biosciences, Marlborough, MA, USA. obraubach@icloud.com., Ajami B; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA. ajami@ohsu.edu.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA. ajami@ohsu.edu.; Department of Neurology and Regenerative Medicine Institute, Cedars Sinai, Los Angeles, CA, USA. ajami@ohsu.edu.
Source: Nature neuroscience [Nat Neurosci] 2026 Jul; Vol. 29 (7), pp. 1599-1614. Date of Electronic Publication: 2026 May 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Sanchez-Molina+P%22">Sanchez-Molina P</searchLink>; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Rosmus+DD%22">Rosmus DD</searchLink>; Institute of Anatomy, Leipzig University, Leipzig, Germany.; Cellular Neuroanatomy, Chair of Anatomy and Cell Biology, Institute of Theoretical Medicine, University of Augsburg, Augsburg, Germany.; Department of Neurology, Leipzig University Medical Center, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Brownell+D%22">Brownell D</searchLink>; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Meral+M%22">Meral M</searchLink>; ariadne.ai AG, Lucerne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gohlich+C%22">Gohlich C</searchLink>; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Pratapa+A%22">Pratapa A</searchLink>; Akoya Biosciences, Marlborough, MA, USA.<br /><searchLink fieldCode="AU" term="%22Peymanfar+Y%22">Peymanfar Y</searchLink>; Akoya Biosciences, Marlborough, MA, USA.<br /><searchLink fieldCode="AU" term="%22Whitley+A%22">Whitley A</searchLink>; Akoya Biosciences, Marlborough, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hou+Y%22">Hou Y</searchLink>; Akoya Biosciences, Marlborough, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nikulina+N%22">Nikulina N</searchLink>; Akoya Biosciences, Marlborough, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bogachuk+A%22">Bogachuk A</searchLink>; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Bouchard+EL%22">Bouchard EL</searchLink>; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Chiot+A%22">Chiot A</searchLink>; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Kuhrt+H%22">Kuhrt H</searchLink>; Institute of Anatomy, Leipzig University, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Wieghofer+P%22">Wieghofer P</searchLink>; Institute of Anatomy, Leipzig University, Leipzig, Germany.; Cellular Neuroanatomy, Chair of Anatomy and Cell Biology, Institute of Theoretical Medicine, University of Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Woltjer+R%22">Woltjer R</searchLink>; Department of Pathology, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Svara+F%22">Svara F</searchLink>; ariadne.ai AG, Lucerne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Braubach+O%22">Braubach O</searchLink>; Akoya Biosciences, Marlborough, MA, USA. obraubach@icloud.com.<br /><searchLink fieldCode="AU" term="%22Ajami+B%22">Ajami B</searchLink>; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA. ajami@ohsu.edu.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA. ajami@ohsu.edu.; Department of Neurology and Regenerative Medicine Institute, Cedars Sinai, Los Angeles, CA, USA. ajami@ohsu.edu.
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  Data: <searchLink fieldCode="JN" term="%229809671%22">Nature neuroscience</searchLink> [Nat Neurosci] 2026 Jul; Vol. 29 (7), pp. 1599-1614. <i>Date of Electronic Publication: </i>2026 May 18.
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