Evaluating reasoning models for therapy recommendations in gastrointestinal stromal tumors: expert and LLM-based evaluations of OpenAI o1 and DeepSeek-R1.

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Title: Evaluating reasoning models for therapy recommendations in gastrointestinal stromal tumors: expert and LLM-based evaluations of OpenAI o1 and DeepSeek-R1.
Authors: Harbrücker M; Department of Surgery, Medical Faculty Mannheim, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.; DKFZ-Hector Cancer Institute, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Menge F; Department of Surgery, Medical Faculty Mannheim, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany., Taebi A; Department of Surgery, Medical Faculty Mannheim, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany., Nörenberg D; Department of Radiology and Nuclear Medicine, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany., Speer T; Independent Researcher, Ludwigshafen Am Rhein, Germany., Reißfelder C; Department of Surgery, Medical Faculty Mannheim, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.; DKFZ-Hector Cancer Institute, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Hohenberger P; Division of Surgical Oncology & Thoracic Surgery, Department of Surgery, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Jakob J; Department of Surgery, Medical Faculty Mannheim, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany., Li C; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Sarcoma Center, Peking University Cancer Hospital & Institute, Beijing, China. chengpengli@bjmu.edu.cn., Yang C; Department of Surgery, Medical Faculty Mannheim, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany. Cui.Yang@medma.uni-heidelberg.de.
Source: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2026 May 18; Vol. 152 (7). Date of Electronic Publication: 2026 May 18.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7902060 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1335 (Electronic) Linking ISSN: 01715216 NLM ISO Abbreviation: J Cancer Res Clin Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-1335
DOI:10.1007/s00432-026-06489-7