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Design, Synthesis, and Evaluation of Coumarin-Rasagiline Hybrids as Multifunctional Neuroprotective Agents.

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Title: Design, Synthesis, and Evaluation of Coumarin-Rasagiline Hybrids as Multifunctional Neuroprotective Agents.
Authors: Carneiro A; Departamento Química Orgánica, Facultad de Farmacia, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal., Barreiro S; Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal.; Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Porto, Portugal.; UCIBIO - Applied Molecular Biosciences Unit, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal., Machado CS; Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal.; RISE-Health, Faculty of Medicine, University of Porto, Porto, Portugal., Pinto M; RISE-Health, Faculty of Medicine, University of Porto, Porto, Portugal., Chavarria D; RISE-Health, Faculty of Medicine, University of Porto, Porto, Portugal., Novás M; Departamento Química Orgánica, Facultad de Farmacia, Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Crucitti D; Departamento Química Orgánica, Facultad de Farmacia, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Group of Computational Genomics and Hematology (GreCoXen), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Fernandes C; RISE-Health, Faculty of Medicine, University of Porto, Porto, Portugal., Matos MJ; Departamento Química Orgánica, Facultad de Farmacia, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Source: ChemMedChem [ChemMedChem] 2026 May 27; Vol. 21 (10), pp. e70307.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE
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  Data: Design, Synthesis, and Evaluation of Coumarin-Rasagiline Hybrids as Multifunctional Neuroprotective Agents.
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  Data: <searchLink fieldCode="AU" term="%22Carneiro+A%22">Carneiro A</searchLink>; Departamento Química Orgánica, Facultad de Farmacia, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Barreiro+S%22">Barreiro S</searchLink>; Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal.; Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Porto, Portugal.; UCIBIO - Applied Molecular Biosciences Unit, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Machado+CS%22">Machado CS</searchLink>; Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal.; RISE-Health, Faculty of Medicine, University of Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Pinto+M%22">Pinto M</searchLink>; RISE-Health, Faculty of Medicine, University of Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Chavarria+D%22">Chavarria D</searchLink>; RISE-Health, Faculty of Medicine, University of Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Novás+M%22">Novás M</searchLink>; Departamento Química Orgánica, Facultad de Farmacia, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Crucitti+D%22">Crucitti D</searchLink>; Departamento Química Orgánica, Facultad de Farmacia, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Group of Computational Genomics and Hematology (GreCoXen), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Fernandes+C%22">Fernandes C</searchLink>; RISE-Health, Faculty of Medicine, University of Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Matos+MJ%22">Matos MJ</searchLink>; Departamento Química Orgánica, Facultad de Farmacia, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
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  Data: <searchLink fieldCode="JN" term="%22101259013%22">ChemMedChem</searchLink> [ChemMedChem] 2026 May 27; Vol. 21 (10), pp. e70307.
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              Text: 2026 May 27
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