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Abl kinase activation promotes axon initial segment disassembly and protein sorting defects in Alzheimer's disease.

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Title: Abl kinase activation promotes axon initial segment disassembly and protein sorting defects in Alzheimer's disease.
Authors: Stuardo N; Biological Sciences Faculty, Pontificia Universidad Catolica de Chile, Santiago, 8331150, Chile. nstuardo@bio.puc.cl.; Millennium Institute On Immunology and Immunotherapy, Pontificia Universidad Catolica de Chile, Santiago, 8331150, Chile. nstuardo@bio.puc.cl., Cáceres-Quezada Á; Biological Sciences Faculty, Pontificia Universidad Catolica de Chile, Santiago, 8331150, Chile., Guzmán D; Biological Sciences Faculty, Pontificia Universidad Catolica de Chile, Santiago, 8331150, Chile.; Millennium Institute On Immunology and Immunotherapy, Pontificia Universidad Catolica de Chile, Santiago, 8331150, Chile., Lamaizon CM; Biological Sciences Faculty, Pontificia Universidad Catolica de Chile, Santiago, 8331150, Chile.; Millennium Institute On Immunology and Immunotherapy, Pontificia Universidad Catolica de Chile, Santiago, 8331150, Chile., Leal R N; Biological Sciences Faculty, Pontificia Universidad Catolica de Chile, Santiago, 8331150, Chile., Koleske AJ; Department of Molecular Biophysics and Biochemistry, Yale School of Medicine, Yale University, New Haven, CT, 06510, USA.; Department of Neuroscience, Yale School of Medicine, Yale University, New Haven, CT, 06510, USA., Álvarez R A; Biological Sciences Faculty, Pontificia Universidad Catolica de Chile, Santiago, 8331150, Chile. aalvarer@uc.cl.; Millennium Institute On Immunology and Immunotherapy, Pontificia Universidad Catolica de Chile, Santiago, 8331150, Chile. aalvarer@uc.cl.
Source: BMC biology [BMC Biol] 2026 May 19; Vol. 24 (1). Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190720 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7007 (Electronic) Linking ISSN: 17417007 NLM ISO Abbreviation: BMC Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1741-7007
DOI:10.1186/s12915-026-02624-5