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Voriconazole therapy and CYP2C19 phenotype: identifying patients who may need alternative antifungal therapy.

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Title: Voriconazole therapy and CYP2C19 phenotype: identifying patients who may need alternative antifungal therapy.
Authors: Wehbe E; School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.; Department of Pharmacy, Westmead Hospital, Sydney, NSW 2145, Australia., Sreeharan T; Department of Pharmacy, Westmead Hospital, Sydney, NSW 2145, Australia., Sutrave G; Westmead Institute for Medical Research, University of Sydney, Sydney, NSW 2145, Australia., Bui J; Department of Pharmacy, Royal North Shore Hospital, Sydney, NSW 2065, Australia., Lau C; Department of Pharmacy, St Vincent's Hospital, Sydney, NSW 2010, Australia., Park JY; Department of Pharmacy, Westmead Hospital, Sydney, NSW 2145, Australia., Sandaradura I; Westmead Institute for Medical Research, University of Sydney, Sydney, NSW 2145, Australia.; Centre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, NSW 2145, Australia.; Sydney Institute for Infectious Diseases, The University of Sydney, Sydney, NSW 2145, Australia., Darley D; Department of Thoracic Medicine, St Vincent's Hospital, Sydney, NSW 2010, Australia., Macdonald P; Heart and Lung Transplant Unit, St Vincent's Hospital, Sydney, NSW 2010, Australia., Milliken S; Department of Haematology, St Vincent's Hospital, Sydney, NSW 2010, Australia., Fung JN; Department of Pharmacy, Westmead Hospital, Sydney, NSW 2145, Australia., Jones G; Department of Chemical Pathology and Clinical Pharmacology, SydPath, St Vincent's Hospital, Sydney, NSW 2010, Australia., Kizny Gordon A; Department of Infectious Diseases and Microbiology, Royal North Shore Hospital, Sydney, NSW 2065, Australia., Kliman D; Department of Haematology, Royal North Shore Hospital, Sydney, NSW 2065, Australia., Lu CY; School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.; Department of Pharmacy, Royal North Shore Hospital, Sydney, NSW 2065, Australia.; Kolling Institute, Faculty of Medicine and Health, The University of Sydney, The Northern Sydney Local Health District, Sydney, NSW 2065, Australia., Marriott D; Department of Clinical Microbiology and Infectious Diseases, St Vincent's Hospital, Sydney, NSW 2010, Australia., Alffenaar JC; School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.; Department of Pharmacy, Westmead Hospital, Sydney, NSW 2145, Australia.; Sydney Institute for Infectious Diseases, The University of Sydney, Sydney, NSW 2145, Australia., Stocker SL; School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.; Department of Pharmacy, Westmead Hospital, Sydney, NSW 2145, Australia.; Sydney Institute for Infectious Diseases, The University of Sydney, Sydney, NSW 2145, Australia.; Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Sydney, NSW 2010, Australia.
Source: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2026 May 05; Vol. 81 (6).
Publication Type: Journal Article; Multicenter Study; Observational Study
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Voriconazole therapy and CYP2C19 phenotype: identifying patients who may need alternative antifungal therapy.
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  Data: <searchLink fieldCode="AU" term="%22Wehbe+E%22">Wehbe E</searchLink>; School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.; Department of Pharmacy, Westmead Hospital, Sydney, NSW 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Sreeharan+T%22">Sreeharan T</searchLink>; Department of Pharmacy, Westmead Hospital, Sydney, NSW 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Sutrave+G%22">Sutrave G</searchLink>; Westmead Institute for Medical Research, University of Sydney, Sydney, NSW 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Bui+J%22">Bui J</searchLink>; Department of Pharmacy, Royal North Shore Hospital, Sydney, NSW 2065, Australia.<br /><searchLink fieldCode="AU" term="%22Lau+C%22">Lau C</searchLink>; Department of Pharmacy, St Vincent's Hospital, Sydney, NSW 2010, Australia.<br /><searchLink fieldCode="AU" term="%22Park+JY%22">Park JY</searchLink>; Department of Pharmacy, Westmead Hospital, Sydney, NSW 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Sandaradura+I%22">Sandaradura I</searchLink>; Westmead Institute for Medical Research, University of Sydney, Sydney, NSW 2145, Australia.; Centre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, NSW 2145, Australia.; Sydney Institute for Infectious Diseases, The University of Sydney, Sydney, NSW 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Darley+D%22">Darley D</searchLink>; Department of Thoracic Medicine, St Vincent's Hospital, Sydney, NSW 2010, Australia.<br /><searchLink fieldCode="AU" term="%22Macdonald+P%22">Macdonald P</searchLink>; Heart and Lung Transplant Unit, St Vincent's Hospital, Sydney, NSW 2010, Australia.<br /><searchLink fieldCode="AU" term="%22Milliken+S%22">Milliken S</searchLink>; Department of Haematology, St Vincent's Hospital, Sydney, NSW 2010, Australia.<br /><searchLink fieldCode="AU" term="%22Fung+JN%22">Fung JN</searchLink>; Department of Pharmacy, Westmead Hospital, Sydney, NSW 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Jones+G%22">Jones G</searchLink>; Department of Chemical Pathology and Clinical Pharmacology, SydPath, St Vincent's Hospital, Sydney, NSW 2010, Australia.<br /><searchLink fieldCode="AU" term="%22Kizny+Gordon+A%22">Kizny Gordon A</searchLink>; Department of Infectious Diseases and Microbiology, Royal North Shore Hospital, Sydney, NSW 2065, Australia.<br /><searchLink fieldCode="AU" term="%22Kliman+D%22">Kliman D</searchLink>; Department of Haematology, Royal North Shore Hospital, Sydney, NSW 2065, Australia.<br /><searchLink fieldCode="AU" term="%22Lu+CY%22">Lu CY</searchLink>; School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.; Department of Pharmacy, Royal North Shore Hospital, Sydney, NSW 2065, Australia.; Kolling Institute, Faculty of Medicine and Health, The University of Sydney, The Northern Sydney Local Health District, Sydney, NSW 2065, Australia.<br /><searchLink fieldCode="AU" term="%22Marriott+D%22">Marriott D</searchLink>; Department of Clinical Microbiology and Infectious Diseases, St Vincent's Hospital, Sydney, NSW 2010, Australia.<br /><searchLink fieldCode="AU" term="%22Alffenaar+JC%22">Alffenaar JC</searchLink>; School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.; Department of Pharmacy, Westmead Hospital, Sydney, NSW 2145, Australia.; Sydney Institute for Infectious Diseases, The University of Sydney, Sydney, NSW 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Stocker+SL%22">Stocker SL</searchLink>; School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.; Department of Pharmacy, Westmead Hospital, Sydney, NSW 2145, Australia.; Sydney Institute for Infectious Diseases, The University of Sydney, Sydney, NSW 2145, Australia.; Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Sydney, NSW 2010, Australia.
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