Microbiome-Directed Therapy for Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Placebo-Controlled Trial of Multistrain Probiotic Supplementation.

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Title: Microbiome-Directed Therapy for Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Placebo-Controlled Trial of Multistrain Probiotic Supplementation.
Authors: Borren NZ; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands., Paulides E; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands., Klaassen MAY; Department of Gastroenterology and Hepatology, Isala Zwolle, Zwolle, The Netherlands.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Alm E; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., van der Woude CJ; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands., Ananthakrishnan AN; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA .
Source: The American journal of gastroenterology [Am J Gastroenterol] 2026 May 19. Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: Wolters Kluwer Health Country of Publication: United States NLM ID: 0421030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1572-0241 (Electronic) Linking ISSN: 00029270 NLM ISO Abbreviation: Am J Gastroenterol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Borren+NZ%22">Borren NZ</searchLink>; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Paulides+E%22">Paulides E</searchLink>; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Klaassen+MAY%22">Klaassen MAY</searchLink>; Department of Gastroenterology and Hepatology, Isala Zwolle, Zwolle, The Netherlands.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Alm+E%22">Alm E</searchLink>; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Xavier+RJ%22">Xavier RJ</searchLink>; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22van+der+Woude+CJ%22">van der Woude CJ</searchLink>; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ananthakrishnan+AN%22">Ananthakrishnan AN</searchLink>; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA .
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      – TitleFull: Microbiome-Directed Therapy for Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Placebo-Controlled Trial of Multistrain Probiotic Supplementation.
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              Text: 2026 May 19
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