Mastication-Induced Electrical Stimulation Activates Prg4+ Chondroprogenitors for Osteoarthritis Therapy.

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Title: Mastication-Induced Electrical Stimulation Activates Prg4+ Chondroprogenitors for Osteoarthritis Therapy.
Authors: Feng SY; Center For TMD and Orofacial Pain, Peking University School and Hospital of Stomatology, Beijing, China.; NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.; Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing, China., Cheng JR; NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.; Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing, China.; Department of Dental Materials and Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, China., Qin Y; Department of Orthopedics, Peking University Third Hospital, Beijing, China., Lei J; Center For TMD and Orofacial Pain, Peking University School and Hospital of Stomatology, Beijing, China.; NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.; Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing, China., Gao CC; Center For TMD and Orofacial Pain, Peking University School and Hospital of Stomatology, Beijing, China.; NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.; Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing, China., Fu HY; NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.; Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing, China.; Department of Dental Materials and Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, China., Wu LP; NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.; Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing, China.; Department of Dental Materials and Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, China., Nguyen TD; Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, USA.; Institute of Materials Science, Polymer Program, University of Connecticut, Storrs, Connecticut, USA.; Department of Mechanical Engineering, University of Connecticut, Storrs, Connecticut, USA., Deng XL; NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.; Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing, China.; Department of Dental Materials and Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, China., Fu KY; Center For TMD and Orofacial Pain, Peking University School and Hospital of Stomatology, Beijing, China.; NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.; Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing, China., Liu Y; NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.; Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing, China.; Department of Dental Materials and Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, China.
Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2026 May 19, pp. e75725. Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
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  Data: Mastication-Induced Electrical Stimulation Activates Prg4<superscript>+</superscript> Chondroprogenitors for Osteoarthritis Therapy.
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  Data: <searchLink fieldCode="AU" term="%22Feng+SY%22">Feng SY</searchLink>; Center For TMD and Orofacial Pain, Peking University School and Hospital of Stomatology, Beijing, China.; NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.; Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Cheng+JR%22">Cheng JR</searchLink>; NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.; Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing, China.; Department of Dental Materials and Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Qin+Y%22">Qin Y</searchLink>; Department of Orthopedics, Peking University Third Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lei+J%22">Lei J</searchLink>; Center For TMD and Orofacial Pain, Peking University School and Hospital of Stomatology, Beijing, China.; NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.; Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Gao+CC%22">Gao CC</searchLink>; Center For TMD and Orofacial Pain, Peking University School and Hospital of Stomatology, Beijing, China.; NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.; Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Fu+HY%22">Fu HY</searchLink>; NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.; Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing, China.; Department of Dental Materials and Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wu+LP%22">Wu LP</searchLink>; NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.; Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing, China.; Department of Dental Materials and Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Nguyen+TD%22">Nguyen TD</searchLink>; Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, USA.; Institute of Materials Science, Polymer Program, University of Connecticut, Storrs, Connecticut, USA.; Department of Mechanical Engineering, University of Connecticut, Storrs, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Deng+XL%22">Deng XL</searchLink>; NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.; Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing, China.; Department of Dental Materials and Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Fu+KY%22">Fu KY</searchLink>; Center For TMD and Orofacial Pain, Peking University School and Hospital of Stomatology, Beijing, China.; NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.; Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; NMPA Center for Innovation and Research in Regulatory Science and Beijing Key Laboratory of Digital Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.; National Center for Stomatology and National Clinical Research Center for Oral Diseases and NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.; Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing, China.; Department of Dental Materials and Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, China.
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