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Metabolic Checkpoints in Cutaneous Squamous Cell Carcinoma: ACSL1 and PPARD Orchestrate Lipid-Ferroptosis Crosstalk via Keratinocyte Remodeling.

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Title: Metabolic Checkpoints in Cutaneous Squamous Cell Carcinoma: ACSL1 and PPARD Orchestrate Lipid-Ferroptosis Crosstalk via Keratinocyte Remodeling.
Authors: Shi XX; Department of Dermatology, The Affiliated Yan' an Hospital of Kunming Medical University, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, Yunnan, 650051, China., Li GY; Department of Burns, Plastic, and Maxillofacial Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650000, China., Yang XY; Department of Dermatology, The Affiliated Yan' an Hospital of Kunming Medical University, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, Yunnan, 650051, China., Zeng ZX; Department of Burns, Plastic, and Maxillofacial Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650000, China., Zhou TT; Department of Dermatology, The Affiliated Yan' an Hospital of Kunming Medical University, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, Yunnan, 650051, China., Zhang YJ; Department of Dermatology, The Affiliated Yan' an Hospital of Kunming Medical University, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, Yunnan, 650051, China., Huang MT; Department of Dermatology, The Affiliated Yan' an Hospital of Kunming Medical University, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, Yunnan, 650051, China., Tang Y; Department of Burns, Plastic, and Maxillofacial Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650000, China. drtangyang@126.com., Xu N; The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, Yunnan, 650100, China. xuning@kmmu.edu.cn.
Source: Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2026 May 19. Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8208561 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0291 (Electronic) Linking ISSN: 02732289 NLM ISO Abbreviation: Appl Biochem Biotechnol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Metabolic Checkpoints in Cutaneous Squamous Cell Carcinoma: ACSL1 and PPARD Orchestrate Lipid-Ferroptosis Crosstalk via Keratinocyte Remodeling.
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  Data: <searchLink fieldCode="AU" term="%22Shi+XX%22">Shi XX</searchLink>; Department of Dermatology, The Affiliated Yan' an Hospital of Kunming Medical University, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, Yunnan, 650051, China.<br /><searchLink fieldCode="AU" term="%22Li+GY%22">Li GY</searchLink>; Department of Burns, Plastic, and Maxillofacial Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650000, China.<br /><searchLink fieldCode="AU" term="%22Yang+XY%22">Yang XY</searchLink>; Department of Dermatology, The Affiliated Yan' an Hospital of Kunming Medical University, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, Yunnan, 650051, China.<br /><searchLink fieldCode="AU" term="%22Zeng+ZX%22">Zeng ZX</searchLink>; Department of Burns, Plastic, and Maxillofacial Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650000, China.<br /><searchLink fieldCode="AU" term="%22Zhou+TT%22">Zhou TT</searchLink>; Department of Dermatology, The Affiliated Yan' an Hospital of Kunming Medical University, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, Yunnan, 650051, China.<br /><searchLink fieldCode="AU" term="%22Zhang+YJ%22">Zhang YJ</searchLink>; Department of Dermatology, The Affiliated Yan' an Hospital of Kunming Medical University, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, Yunnan, 650051, China.<br /><searchLink fieldCode="AU" term="%22Huang+MT%22">Huang MT</searchLink>; Department of Dermatology, The Affiliated Yan' an Hospital of Kunming Medical University, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, Yunnan, 650051, China.<br /><searchLink fieldCode="AU" term="%22Tang+Y%22">Tang Y</searchLink>; Department of Burns, Plastic, and Maxillofacial Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650000, China. drtangyang@126.com.<br /><searchLink fieldCode="AU" term="%22Xu+N%22">Xu N</searchLink>; The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, Yunnan, 650100, China. xuning@kmmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%228208561%22">Applied biochemistry and biotechnology</searchLink> [Appl Biochem Biotechnol] 2026 May 19. <i>Date of Electronic Publication: </i>2026 May 19.
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      – Type: doi
        Value: 10.1007/s12010-026-05734-6
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        Text: English
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      – TitleFull: Metabolic Checkpoints in Cutaneous Squamous Cell Carcinoma: ACSL1 and PPARD Orchestrate Lipid-Ferroptosis Crosstalk via Keratinocyte Remodeling.
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            – D: 19
              M: 05
              Text: 2026 May 19
              Type: published
              Y: 2026
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