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Transcriptome-guided development of a fibrosis-reversal compound reduces skin scarring and allows regeneration via mitochondrial uncoupling.

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Title: Transcriptome-guided development of a fibrosis-reversal compound reduces skin scarring and allows regeneration via mitochondrial uncoupling.
Authors: Chen CY; Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China., Xu R; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, State Key Laboratory of Natural and Biomimetic Drugs, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, Peking University, Beijing 100871, China., Mo M; Plastech Pharmaceutical Technology Co., Ltd, Nanjing 210043, China., Wu J; Plastech Pharmaceutical Technology Co., Ltd, Nanjing 210043, China., Chi J; Plastech Pharmaceutical Technology Co., Ltd, Nanjing 210043, China., Wu ZR; Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China., Wang Y; Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China., Zhong XC; Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China., Lin XY; Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China., Liu Y; Plastech Pharmaceutical Technology Co., Ltd, Nanjing 210043, China., Wu J; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, State Key Laboratory of Natural and Biomimetic Drugs, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, Peking University, Beijing 100871, China., Fang H; Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China., Jia H; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China., Bi H; Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China. Electronic address: bihongsen@bjmu.edu.cn., Yang Y; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China. Electronic address: yyang@pumcderm.cams.cn., Tan WQ; Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China. Electronic address: tanweixxxx@zju.edu.cn., Zhao Y; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, State Key Laboratory of Natural and Biomimetic Drugs, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, Peking University, Beijing 100871, China. Electronic address: yangzhao@pku.edu.cn.
Source: Cell reports. Medicine [Cell Rep Med] 2026 May 19; Vol. 7 (5), pp. 102821.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Transcriptome-guided development of a fibrosis-reversal compound reduces skin scarring and allows regeneration via mitochondrial uncoupling.
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  Data: <searchLink fieldCode="AU" term="%22Chen+CY%22">Chen CY</searchLink>; Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.<br /><searchLink fieldCode="AU" term="%22Xu+R%22">Xu R</searchLink>; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, State Key Laboratory of Natural and Biomimetic Drugs, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, Peking University, Beijing 100871, China.<br /><searchLink fieldCode="AU" term="%22Mo+M%22">Mo M</searchLink>; Plastech Pharmaceutical Technology Co., Ltd, Nanjing 210043, China.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Plastech Pharmaceutical Technology Co., Ltd, Nanjing 210043, China.<br /><searchLink fieldCode="AU" term="%22Chi+J%22">Chi J</searchLink>; Plastech Pharmaceutical Technology Co., Ltd, Nanjing 210043, China.<br /><searchLink fieldCode="AU" term="%22Wu+ZR%22">Wu ZR</searchLink>; Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.<br /><searchLink fieldCode="AU" term="%22Zhong+XC%22">Zhong XC</searchLink>; Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.<br /><searchLink fieldCode="AU" term="%22Lin+XY%22">Lin XY</searchLink>; Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Plastech Pharmaceutical Technology Co., Ltd, Nanjing 210043, China.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, State Key Laboratory of Natural and Biomimetic Drugs, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, Peking University, Beijing 100871, China.<br /><searchLink fieldCode="AU" term="%22Fang+H%22">Fang H</searchLink>; Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China.<br /><searchLink fieldCode="AU" term="%22Jia+H%22">Jia H</searchLink>; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.<br /><searchLink fieldCode="AU" term="%22Bi+H%22">Bi H</searchLink>; Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China. Electronic address: bihongsen@bjmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China. Electronic address: yyang@pumcderm.cams.cn.<br /><searchLink fieldCode="AU" term="%22Tan+WQ%22">Tan WQ</searchLink>; Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China. Electronic address: tanweixxxx@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, State Key Laboratory of Natural and Biomimetic Drugs, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, Peking University, Beijing 100871, China. Electronic address: yangzhao@pku.edu.cn.
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        Value: 10.1016/j.xcrm.2026.102821
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      – Code: eng
        Text: English
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      – TitleFull: Transcriptome-guided development of a fibrosis-reversal compound reduces skin scarring and allows regeneration via mitochondrial uncoupling.
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              Text: 2026 May 19
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