Single-cell transcriptomics reveals anti-inflammatory effects of prednisolone on the hepatic niche in biliary atresia.

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Title: Single-cell transcriptomics reveals anti-inflammatory effects of prednisolone on the hepatic niche in biliary atresia.
Authors: Blakeley PD; Department of Surgery, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR, China., Liu F; Department of Surgery, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR, China., Wu Z; Department of Surgery, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR, China., Tang CSM; Department of Surgery, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR, China.; Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Hong Kong SAR, China., Tam PKH; Faculty of Medicine, Macau University of Science and Technology, Macau SAR, China., Wong KKH; Department of Surgery, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR, China., Lui VCH; Department of Surgery, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR, China. vchlui@hku.hk.; Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Hong Kong SAR, China. vchlui@hku.hk., Chung PHY; Department of Surgery, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR, China. chungphy@hku.hk.
Source: Scientific reports [Sci Rep] 2026 May 19. Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Blakeley+PD%22">Blakeley PD</searchLink>; Department of Surgery, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Liu+F%22">Liu F</searchLink>; Department of Surgery, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; Department of Surgery, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Tang+CSM%22">Tang CSM</searchLink>; Department of Surgery, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR, China.; Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Tam+PKH%22">Tam PKH</searchLink>; Faculty of Medicine, Macau University of Science and Technology, Macau SAR, China.<br /><searchLink fieldCode="AU" term="%22Wong+KKH%22">Wong KKH</searchLink>; Department of Surgery, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Lui+VCH%22">Lui VCH</searchLink>; Department of Surgery, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR, China. vchlui@hku.hk.; Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Hong Kong SAR, China. vchlui@hku.hk.<br /><searchLink fieldCode="AU" term="%22Chung+PHY%22">Chung PHY</searchLink>; Department of Surgery, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong SAR, China. chungphy@hku.hk.
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        Value: 10.1038/s41598-026-48897-2
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              Text: 2026 May 19
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