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Gene-gene interactions between a LMNA variant and common polymorphisms drive early-onset atrial fibrillation.

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Title: Gene-gene interactions between a LMNA variant and common polymorphisms drive early-onset atrial fibrillation.
Authors: Owais A; Department of Medicine, Division of Cardiology, University of Illinois Chicago, Chicago, IL, USA., Chen H; Department of Medicine, Division of Cardiology, University of Illinois Chicago, Chicago, IL, USA., Farooq H; Center for Bioinformatics and Quantitative Biology, University of Illinois Chicago, Chicago, IL, USA.; Richard and Loan Hill Department of Biomedical Engineering, University of Illinois Chicago, Chicago, IL, USA., Thami PK; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, Imperial College London, London, UK., McGurk KA; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, Imperial College London, London, UK.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Powell GJ; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, Imperial College London, London, UK., DeSantiago J; Department of Medicine, Division of Cardiology, University of Illinois Chicago, Chicago, IL, USA., Abbas T; Department of Biochemistry & Molecular Genetics, University of Illinois Chicago, Chicago, IL, USA., Sridhar A; Department of Medicine, Division of Cardiology, University of Illinois Chicago, Chicago, IL, USA., Pavel A; Department of Medicine, Division of Cardiology, University of Illinois Chicago, Chicago, IL, USA., Webster G; Section of Electrophysiology, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL, USA., Merrill B; Department of Biochemistry & Molecular Genetics, University of Illinois Chicago, Chicago, IL, USA., Ware JS; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, Imperial College London, London, UK.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Ng FS; National Heart and Lung Institute, Imperial College London, London, UK., Darbar D; Department of Medicine, Penn State College of Medicine, Hershey, PA, USA. ddarbar@pennstatehealth.psu.edu.
Source: Nature communications [Nat Commun] 2026 May 19; Vol. 17 (1). Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Owais+A%22">Owais A</searchLink>; Department of Medicine, Division of Cardiology, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of Medicine, Division of Cardiology, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Farooq+H%22">Farooq H</searchLink>; Center for Bioinformatics and Quantitative Biology, University of Illinois Chicago, Chicago, IL, USA.; Richard and Loan Hill Department of Biomedical Engineering, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Thami+PK%22">Thami PK</searchLink>; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22McGurk+KA%22">McGurk KA</searchLink>; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, Imperial College London, London, UK.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Powell+GJ%22">Powell GJ</searchLink>; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22DeSantiago+J%22">DeSantiago J</searchLink>; Department of Medicine, Division of Cardiology, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Abbas+T%22">Abbas T</searchLink>; Department of Biochemistry & Molecular Genetics, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Sridhar+A%22">Sridhar A</searchLink>; Department of Medicine, Division of Cardiology, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Pavel+A%22">Pavel A</searchLink>; Department of Medicine, Division of Cardiology, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Webster+G%22">Webster G</searchLink>; Section of Electrophysiology, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Merrill+B%22">Merrill B</searchLink>; Department of Biochemistry & Molecular Genetics, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Ware+JS%22">Ware JS</searchLink>; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, Imperial College London, London, UK.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Ng+FS%22">Ng FS</searchLink>; National Heart and Lung Institute, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Darbar+D%22">Darbar D</searchLink>; Department of Medicine, Penn State College of Medicine, Hershey, PA, USA. ddarbar@pennstatehealth.psu.edu.
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