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Dual CAR-NK cells targeting PD-L1 and ErbB2 (HER2) exhibit cooperative CAR signaling and counteract solid tumor heterogeneity.

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Title: Dual CAR-NK cells targeting PD-L1 and ErbB2 (HER2) exhibit cooperative CAR signaling and counteract solid tumor heterogeneity.
Authors: Freudenberg-Jahn K; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Ben-Horin I; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany., Murali Shankar N; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Schuldt M; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Ortiz-Montero P; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Loureiro LR; Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany., Rackwitz W; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Opitz C; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Krutz L; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Breither T; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Oberoi P; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany., Häcker A; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany., Jäger D; Department of Medical Oncology, National Center for Tumor Diseases Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Kuhlmann JD; Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; National Center for Tumor Diseases (NCT), NCT/UCC Dresden, a Partnership Between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Dresden and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany., Wimberger P; Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; National Center for Tumor Diseases (NCT), NCT/UCC Dresden, a Partnership Between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Dresden and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany., Künzel SR; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Hölig K; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Feldmann A; Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany., Bachmann M; Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.; National Center for Tumor Diseases (NCT), University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany.; Tumor Immunology, University Cancer Center (UCC), University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany., Wels WS; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany., Tonn T; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany. t.tonn@blutspende.de.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany. t.tonn@blutspende.de.; German Red Cross Blood Donation Service Baden-Württemberg-Hessen gGmbH, Mannheim, Germany. t.tonn@blutspende.de.; Institute for Transfusion Medicine and Immunohematology, Clinics of the Goethe University, Frankfurt am Main, Germany. t.tonn@blutspende.de., Eitler J; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany. j.eitler@blutspende.de.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany. j.eitler@blutspende.de.; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany. j.eitler@blutspende.de.
Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2026 May 19; Vol. 45 (1). Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dual CAR-NK cells targeting PD-L1 and ErbB2 (HER2) exhibit cooperative CAR signaling and counteract solid tumor heterogeneity.
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  Data: <searchLink fieldCode="AU" term="%22Freudenberg-Jahn+K%22">Freudenberg-Jahn K</searchLink>; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Ben-Horin+I%22">Ben-Horin I</searchLink>; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Murali+Shankar+N%22">Murali Shankar N</searchLink>; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Schuldt+M%22">Schuldt M</searchLink>; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Ortiz-Montero+P%22">Ortiz-Montero P</searchLink>; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Loureiro+LR%22">Loureiro LR</searchLink>; Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Rackwitz+W%22">Rackwitz W</searchLink>; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Opitz+C%22">Opitz C</searchLink>; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Krutz+L%22">Krutz L</searchLink>; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Breither+T%22">Breither T</searchLink>; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Oberoi+P%22">Oberoi P</searchLink>; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Häcker+A%22">Häcker A</searchLink>; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Jäger+D%22">Jäger D</searchLink>; Department of Medical Oncology, National Center for Tumor Diseases Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kuhlmann+JD%22">Kuhlmann JD</searchLink>; Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; National Center for Tumor Diseases (NCT), NCT/UCC Dresden, a Partnership Between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Dresden and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wimberger+P%22">Wimberger P</searchLink>; Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; National Center for Tumor Diseases (NCT), NCT/UCC Dresden, a Partnership Between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Dresden and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Künzel+SR%22">Künzel SR</searchLink>; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Hölig+K%22">Hölig K</searchLink>; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Feldmann+A%22">Feldmann A</searchLink>; Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Bachmann+M%22">Bachmann M</searchLink>; Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.; National Center for Tumor Diseases (NCT), University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany.; Tumor Immunology, University Cancer Center (UCC), University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Wels+WS%22">Wels WS</searchLink>; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Tonn+T%22">Tonn T</searchLink>; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany. t.tonn@blutspende.de.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany. t.tonn@blutspende.de.; German Red Cross Blood Donation Service Baden-Württemberg-Hessen gGmbH, Mannheim, Germany. t.tonn@blutspende.de.; Institute for Transfusion Medicine and Immunohematology, Clinics of the Goethe University, Frankfurt am Main, Germany. t.tonn@blutspende.de.<br /><searchLink fieldCode="AU" term="%22Eitler+J%22">Eitler J</searchLink>; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany. j.eitler@blutspende.de.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany. j.eitler@blutspende.de.; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany. j.eitler@blutspende.de.
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  Data: <searchLink fieldCode="JN" term="%228308647%22">Journal of experimental & clinical cancer research : CR</searchLink> [J Exp Clin Cancer Res] 2026 May 19; Vol. 45 (1). <i>Date of Electronic Publication: </i>2026 May 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8308647 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1756-9966 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203929078%22">03929078 </searchLink><i>NLM ISO Abbreviation: </i>J Exp Clin Cancer Res <i>Subsets: </i>MEDLINE
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