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Discovery and Structural Optimization of BRD4-Selective Monovalent Direct Degraders.

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Title: Discovery and Structural Optimization of BRD4-Selective Monovalent Direct Degraders.
Authors: Leriche G; Plexium, 9330 Scranton Road, San Diego, California 92121, United States., Barmare F; Plexium, 9330 Scranton Road, San Diego, California 92121, United States., Toth JI; Plexium, 9330 Scranton Road, San Diego, California 92121, United States., Jamborcic A; Plexium, 9330 Scranton Road, San Diego, California 92121, United States., Kampert TL; Plexium, 9330 Scranton Road, San Diego, California 92121, United States., Steadman K; Plexium, 9330 Scranton Road, San Diego, California 92121, United States., Yang L; Plexium, 9330 Scranton Road, San Diego, California 92121, United States., Fish S; Plexium, 9330 Scranton Road, San Diego, California 92121, United States., Daniele E; Plexium, 9330 Scranton Road, San Diego, California 92121, United States., McCarrick M; Plexium, 9330 Scranton Road, San Diego, California 92121, United States., Kallel EA; Plexium, 9330 Scranton Road, San Diego, California 92121, United States., Li X; Plexium, 9330 Scranton Road, San Diego, California 92121, United States., Thompson PA; Plexium, 9330 Scranton Road, San Diego, California 92121, United States., Parker GS; Plexium, 9330 Scranton Road, San Diego, California 92121, United States., Freeman-Cook K; Plexium, 9330 Scranton Road, San Diego, California 92121, United States., Bailey S; Plexium, 9330 Scranton Road, San Diego, California 92121, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2026 Apr 06; Vol. 17 (5), pp. 1106-1113. Date of Electronic Publication: 2026 Apr 06 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="JN" term="%22101521073%22">ACS medicinal chemistry letters</searchLink> [ACS Med Chem Lett] 2026 Apr 06; Vol. 17 (5), pp. 1106-1113. <i>Date of Electronic Publication: </i>2026 Apr 06 (<i>Print Publication: </i>2026).
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              Text: 2026 Apr 06
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