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Spirocyclohexane-Chroman-4-one Derivatives as Selectively Cytotoxic Agents in Breast Cancer Models.

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Title: Spirocyclohexane-Chroman-4-one Derivatives as Selectively Cytotoxic Agents in Breast Cancer Models.
Authors: Ipatova DA; Department of Chemistry, Moscow State University (MSU), Leninskie Gory, Building 1/3, Moscow 119991, Russia., Ikonnikova VA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia., Kungurtsev KD; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia., Kashapov AI; Department of Chemistry, Moscow State University (MSU), Leninskie Gory, Building 1/3, Moscow 119991, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia., Shafikov RR; Department of Chemistry, Moscow State University (MSU), Leninskie Gory, Building 1/3, Moscow 119991, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia., Kartsev VG; InterBioScreen Ltd., Institutsky Prospect, 7a, Chernogolovka 142432, Russia., Glushkov AK; Department of Chemistry, Moscow State University (MSU), Leninskie Gory, Building 1/3, Moscow 119991, Russia., Myasnyanko IN; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia.; Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997, Russia., Baranov MS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia.; Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997, Russia., Mikhaylov AA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia.; Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997, Russia., Dontsova OA; Department of Chemistry, Moscow State University (MSU), Leninskie Gory, Building 1/3, Moscow 119991, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia., Skvortsov DA; Department of Chemistry, Moscow State University (MSU), Leninskie Gory, Building 1/3, Moscow 119991, Russia.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2026 Apr 29; Vol. 17 (5), pp. 1114-1120. Date of Electronic Publication: 2026 Apr 29 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
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  Data: Spirocyclohexane-Chroman-4-one Derivatives as Selectively Cytotoxic Agents in Breast Cancer Models.
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  Data: <searchLink fieldCode="AU" term="%22Ipatova+DA%22">Ipatova DA</searchLink>; Department of Chemistry, Moscow State University (MSU), Leninskie Gory, Building 1/3, Moscow 119991, Russia.<br /><searchLink fieldCode="AU" term="%22Ikonnikova+VA%22">Ikonnikova VA</searchLink>; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia.<br /><searchLink fieldCode="AU" term="%22Kungurtsev+KD%22">Kungurtsev KD</searchLink>; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia.<br /><searchLink fieldCode="AU" term="%22Kashapov+AI%22">Kashapov AI</searchLink>; Department of Chemistry, Moscow State University (MSU), Leninskie Gory, Building 1/3, Moscow 119991, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia.<br /><searchLink fieldCode="AU" term="%22Shafikov+RR%22">Shafikov RR</searchLink>; Department of Chemistry, Moscow State University (MSU), Leninskie Gory, Building 1/3, Moscow 119991, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia.<br /><searchLink fieldCode="AU" term="%22Kartsev+VG%22">Kartsev VG</searchLink>; InterBioScreen Ltd., Institutsky Prospect, 7a, Chernogolovka 142432, Russia.<br /><searchLink fieldCode="AU" term="%22Glushkov+AK%22">Glushkov AK</searchLink>; Department of Chemistry, Moscow State University (MSU), Leninskie Gory, Building 1/3, Moscow 119991, Russia.<br /><searchLink fieldCode="AU" term="%22Myasnyanko+IN%22">Myasnyanko IN</searchLink>; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia.; Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997, Russia.<br /><searchLink fieldCode="AU" term="%22Baranov+MS%22">Baranov MS</searchLink>; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia.; Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997, Russia.<br /><searchLink fieldCode="AU" term="%22Mikhaylov+AA%22">Mikhaylov AA</searchLink>; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia.; Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997, Russia.<br /><searchLink fieldCode="AU" term="%22Dontsova+OA%22">Dontsova OA</searchLink>; Department of Chemistry, Moscow State University (MSU), Leninskie Gory, Building 1/3, Moscow 119991, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia.<br /><searchLink fieldCode="AU" term="%22Skvortsov+DA%22">Skvortsov DA</searchLink>; Department of Chemistry, Moscow State University (MSU), Leninskie Gory, Building 1/3, Moscow 119991, Russia.
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