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Insulin increases expression of cannabinoid receptor 1 by suppressing lysosomal degradation via ERK signaling pathway.

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Title: Insulin increases expression of cannabinoid receptor 1 by suppressing lysosomal degradation via ERK signaling pathway.
Authors: Liu SY; Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Ting CH; Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.; Department of Pathology, MacKay Memorial Hospital, Taipei 104217, Taiwan.; Department of Medicine, MacKay Medical College, New Taipei City 252005, Taiwan., Hwang GS; Department of Nursing, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan., Chen CW; Department of Physical Education, Health, and Recreation, Teachers College, National Chiayi University, Chiayi 621302, Taiwan., Chen LK; Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Ho PH; Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Lee PH; Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Wu GL; Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Yin WH; Division of Cardiology, Cheng-Hsin General Hospital, Taipei 112401, Taiwan.; Heart Center, Cheng-Hsin General Hospital, Taipei 112401, Taiwan., Wu LY; Department of Bioscience Technology, College of Science, Chung-Yuan Christian University, Chung Li 320314, Taiwan., Seow KM; Department of Obstetrics and Gynecology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 111045, Taiwan.; Department of Obstetrics and Gynecology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Lin HF; Division of Trauma, Department of Surgery, Far-Eastern Memorial Hospital, New Taipei City 220216, Taiwan.; Graduate Institute of Medicine, Yuan Ze University, Taoyuan 320315, Taiwan., Juan CC; Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.; Department of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan.
Source: International journal of medical sciences [Int J Med Sci] 2026 May 01; Vol. 23 (6), pp. 2027-2038. Date of Electronic Publication: 2026 May 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101213954 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-1907 (Electronic) Linking ISSN: 14491907 NLM ISO Abbreviation: Int J Med Sci Subsets: MEDLINE
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  Data: Insulin increases expression of cannabinoid receptor 1 by suppressing lysosomal degradation via ERK signaling pathway.
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  Data: <searchLink fieldCode="AU" term="%22Liu+SY%22">Liu SY</searchLink>; Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ting+CH%22">Ting CH</searchLink>; Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.; Department of Pathology, MacKay Memorial Hospital, Taipei 104217, Taiwan.; Department of Medicine, MacKay Medical College, New Taipei City 252005, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hwang+GS%22">Hwang GS</searchLink>; Department of Nursing, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CW%22">Chen CW</searchLink>; Department of Physical Education, Health, and Recreation, Teachers College, National Chiayi University, Chiayi 621302, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+LK%22">Chen LK</searchLink>; Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ho+PH%22">Ho PH</searchLink>; Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+PH%22">Lee PH</searchLink>; Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+GL%22">Wu GL</searchLink>; Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yin+WH%22">Yin WH</searchLink>; Division of Cardiology, Cheng-Hsin General Hospital, Taipei 112401, Taiwan.; Heart Center, Cheng-Hsin General Hospital, Taipei 112401, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+LY%22">Wu LY</searchLink>; Department of Bioscience Technology, College of Science, Chung-Yuan Christian University, Chung Li 320314, Taiwan.<br /><searchLink fieldCode="AU" term="%22Seow+KM%22">Seow KM</searchLink>; Department of Obstetrics and Gynecology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 111045, Taiwan.; Department of Obstetrics and Gynecology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+HF%22">Lin HF</searchLink>; Division of Trauma, Department of Surgery, Far-Eastern Memorial Hospital, New Taipei City 220216, Taiwan.; Graduate Institute of Medicine, Yuan Ze University, Taoyuan 320315, Taiwan.<br /><searchLink fieldCode="AU" term="%22Juan+CC%22">Juan CC</searchLink>; Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.; Department of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101213954%22">International journal of medical sciences</searchLink> [Int J Med Sci] 2026 May 01; Vol. 23 (6), pp. 2027-2038. <i>Date of Electronic Publication: </i>2026 May 01 (<i>Print Publication: </i>2026).
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              Text: 2026 May 01
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