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Sex and Age Specific Genetic Risk Across the Dilated and Arrhythmogenic Cardiomyopathy Spectrum: Insights From the SHaRe Registry.

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Title: Sex and Age Specific Genetic Risk Across the Dilated and Arrhythmogenic Cardiomyopathy Spectrum: Insights From the SHaRe Registry.
Authors: Stroeks SLVM; Department of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands; KU Leuven, Cardiovascular Sciences, Leuven, Belgium; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands., Bart NK; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Rossano J; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Claggett B; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Beelen NJ; Department of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands., Buchan RJ; Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Day S; University of Pennsylvania, Penn Medicine, Philadelphia, Pennsylvania, USA., Fornaro A; Meyer Children's Hospital IRCCS, Florence, Italy., Halliday BP; Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Wheeler MT; Stanford University School of Medicine, Stanford, California, USA., Hammersley DJ; Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Helms A; University of Michigan, Ann Arbor, Michigan, USA., Heymans ABM; Department of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands., Ho CY; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Khan SS; Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Lin K; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Lota A; Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Merlo M; Department of Cardiology, Azienda Sanitaria-Universitaria Integrata Trieste, University of Trieste, Trieste, Italy; Member of ERN-Heart GUARD., Mestroni L; University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Olivotto I; Meyer Children's Hospital IRCCS, Florence, Italy., Owens A; University of Pennsylvania, Penn Medicine, Philadelphia, Pennsylvania, USA., Seidman CE; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Shore S; University of Michigan, Ann Arbor, Michigan, USA., Sinnette C; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Sinagra G; Department of Cardiology, Azienda Sanitaria-Universitaria Integrata Trieste, University of Trieste, Trieste, Italy; Member of ERN-Heart GUARD., Stevenson LW; Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA., Stewart GC; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Theotakis P; Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Venner MFGHM; Department of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands., Ware JS; Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Taylor MRG; University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Verdonschot JAJ; Department of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands., Wilsbacher L; Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Prasad S; Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Heymans SR; Department of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands; KU Leuven, Cardiovascular Sciences, Leuven, Belgium., Parikh VN; Stanford University School of Medicine, Stanford, California, USA., Tayal U; Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom; The George Institute for Global Health, London, United Kingdom. Electronic address: u.tayal14@imperial.ac.uk., Lakdawala NK; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Corporate Authors: DCM/ACM SHaRe Investigators
Source: Journal of the American College of Cardiology [J Am Coll Cardiol] 2026 Jun 30; Vol. 87 (25), pp. 3573-3588. Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8301365 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-3597 (Electronic) Linking ISSN: 07351097 NLM ISO Abbreviation: J Am Coll Cardiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sex and Age Specific Genetic Risk Across the Dilated and Arrhythmogenic Cardiomyopathy Spectrum: Insights From the SHaRe Registry.
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Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Day+S%22">Day S</searchLink>; University of Pennsylvania, Penn Medicine, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Fornaro+A%22">Fornaro A</searchLink>; Meyer Children's Hospital IRCCS, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Halliday+BP%22">Halliday BP</searchLink>; Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wheeler+MT%22">Wheeler MT</searchLink>; Stanford University School of Medicine, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Hammersley+DJ%22">Hammersley DJ</searchLink>; Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Helms+A%22">Helms A</searchLink>; University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Heymans+ABM%22">Heymans ABM</searchLink>; Department of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ho+CY%22">Ho CY</searchLink>; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Khan+SS%22">Khan SS</searchLink>; Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Lin+K%22">Lin K</searchLink>; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Lota+A%22">Lota A</searchLink>; Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Merlo+M%22">Merlo M</searchLink>; Department of Cardiology, Azienda Sanitaria-Universitaria Integrata Trieste, University of Trieste, Trieste, Italy; Member of ERN-Heart GUARD.<br /><searchLink fieldCode="AU" term="%22Mestroni+L%22">Mestroni L</searchLink>; University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Olivotto+I%22">Olivotto I</searchLink>; Meyer Children's Hospital IRCCS, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Owens+A%22">Owens A</searchLink>; University of Pennsylvania, Penn Medicine, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Seidman+CE%22">Seidman CE</searchLink>; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Shore+S%22">Shore S</searchLink>; University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Sinnette+C%22">Sinnette C</searchLink>; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Sinagra+G%22">Sinagra G</searchLink>; Department of Cardiology, Azienda Sanitaria-Universitaria Integrata Trieste, University of Trieste, Trieste, Italy; Member of ERN-Heart GUARD.<br /><searchLink fieldCode="AU" term="%22Stevenson+LW%22">Stevenson LW</searchLink>; Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Stewart+GC%22">Stewart GC</searchLink>; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Theotakis+P%22">Theotakis P</searchLink>; Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Venner+MFGHM%22">Venner MFGHM</searchLink>; Department of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ware+JS%22">Ware JS</searchLink>; Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Taylor+MRG%22">Taylor MRG</searchLink>; University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Verdonschot+JAJ%22">Verdonschot JAJ</searchLink>; Department of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wilsbacher+L%22">Wilsbacher L</searchLink>; Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Prasad+S%22">Prasad S</searchLink>; Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Heymans+SR%22">Heymans SR</searchLink>; Department of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands; KU Leuven, Cardiovascular Sciences, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Parikh+VN%22">Parikh VN</searchLink>; Stanford University School of Medicine, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Tayal+U%22">Tayal U</searchLink>; Royal Brompton & Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom; The George Institute for Global Health, London, United Kingdom. Electronic address: u.tayal14@imperial.ac.uk.<br /><searchLink fieldCode="AU" term="%22Lakdawala+NK%22">Lakdawala NK</searchLink>; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
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