Human islet amyloid polypeptide aggregation upregulates the mitochondrial cholesterol transport protein StAR and induces mitochondrial dysfunction in beta cells.

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Title: Human islet amyloid polypeptide aggregation upregulates the mitochondrial cholesterol transport protein StAR and induces mitochondrial dysfunction in beta cells.
Authors: Hogan MF; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA., Akter R; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA., Aplin AC; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA., Templin AT; VA Puget Sound Health Care System, Seattle, WA, USA. templin@iu.edu.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA. templin@iu.edu.; Department of Medicine, Roudebush Veterans Affairs Medical Center, Indianapolis, IN, USA. templin@iu.edu.; Indiana University School of Medicine, Indianapolis, IN, USA. templin@iu.edu., Esser N; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.; Laboratory of Immunometabolism and Nutrition, GIGA-I3, CHU Liège, University of Liège, Liège, Belgium., Meier DT; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Biomedicine, University of Basel, Basel, Switzerland., Fountaine BS; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA., Castillo JJ; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA., El-Osta A; Epigenetics in Human Health and Disease Program, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia., Hull-Meichle RL; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Cell Biology, University of Alberta, Edmonton, AB, Canada., Zraika S; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA., Kahn SE; VA Puget Sound Health Care System, Seattle, WA, USA. skahn@uw.edu.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA. skahn@uw.edu.
Source: Diabetologia [Diabetologia] 2026 Aug; Vol. 69 (8), pp. 2294-2306. Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0428
DOI:10.1007/s00125-026-06749-8