Human islet amyloid polypeptide aggregation upregulates the mitochondrial cholesterol transport protein StAR and induces mitochondrial dysfunction in beta cells.
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| Title: | Human islet amyloid polypeptide aggregation upregulates the mitochondrial cholesterol transport protein StAR and induces mitochondrial dysfunction in beta cells. |
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| Authors: | Hogan MF; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA., Akter R; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA., Aplin AC; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA., Templin AT; VA Puget Sound Health Care System, Seattle, WA, USA. templin@iu.edu.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA. templin@iu.edu.; Department of Medicine, Roudebush Veterans Affairs Medical Center, Indianapolis, IN, USA. templin@iu.edu.; Indiana University School of Medicine, Indianapolis, IN, USA. templin@iu.edu., Esser N; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.; Laboratory of Immunometabolism and Nutrition, GIGA-I3, CHU Liège, University of Liège, Liège, Belgium., Meier DT; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Biomedicine, University of Basel, Basel, Switzerland., Fountaine BS; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA., Castillo JJ; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA., El-Osta A; Epigenetics in Human Health and Disease Program, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia., Hull-Meichle RL; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Cell Biology, University of Alberta, Edmonton, AB, Canada., Zraika S; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA., Kahn SE; VA Puget Sound Health Care System, Seattle, WA, USA. skahn@uw.edu.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA. skahn@uw.edu. |
| Source: | Diabetologia [Diabetologia] 2026 Aug; Vol. 69 (8), pp. 2294-2306. Date of Electronic Publication: 2026 May 20. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42159696 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Human islet amyloid polypeptide aggregation upregulates the mitochondrial cholesterol transport protein StAR and induces mitochondrial dysfunction in beta cells. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Hogan+MF%22">Hogan MF</searchLink>; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Akter+R%22">Akter R</searchLink>; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Aplin+AC%22">Aplin AC</searchLink>; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Templin+AT%22">Templin AT</searchLink>; VA Puget Sound Health Care System, Seattle, WA, USA. templin@iu.edu.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA. templin@iu.edu.; Department of Medicine, Roudebush Veterans Affairs Medical Center, Indianapolis, IN, USA. templin@iu.edu.; Indiana University School of Medicine, Indianapolis, IN, USA. templin@iu.edu.<br /><searchLink fieldCode="AU" term="%22Esser+N%22">Esser N</searchLink>; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.; Laboratory of Immunometabolism and Nutrition, GIGA-I3, CHU Liège, University of Liège, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Meier+DT%22">Meier DT</searchLink>; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Biomedicine, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fountaine+BS%22">Fountaine BS</searchLink>; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Castillo+JJ%22">Castillo JJ</searchLink>; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22El-Osta+A%22">El-Osta A</searchLink>; Epigenetics in Human Health and Disease Program, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hull-Meichle+RL%22">Hull-Meichle RL</searchLink>; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Cell Biology, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Zraika+S%22">Zraika S</searchLink>; VA Puget Sound Health Care System, Seattle, WA, USA.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Kahn+SE%22">Kahn SE</searchLink>; VA Puget Sound Health Care System, Seattle, WA, USA. skahn@uw.edu.; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA. skahn@uw.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220006777%22">Diabetologia</searchLink> [Diabetologia] 2026 Aug; Vol. 69 (8), pp. 2294-2306. <i>Date of Electronic Publication: </i>2026 May 20. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0006777 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0428 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220012186X%22">0012186X </searchLink><i>NLM ISO Abbreviation: </i>Diabetologia <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42159696 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00125-026-06749-8 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 2294 Titles: – TitleFull: Human islet amyloid polypeptide aggregation upregulates the mitochondrial cholesterol transport protein StAR and induces mitochondrial dysfunction in beta cells. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hogan MF – PersonEntity: Name: NameFull: Akter R – PersonEntity: Name: NameFull: Aplin AC – PersonEntity: Name: NameFull: Templin AT – PersonEntity: Name: NameFull: Esser N – PersonEntity: Name: NameFull: Meier DT – PersonEntity: Name: NameFull: Fountaine BS – PersonEntity: Name: NameFull: Castillo JJ – PersonEntity: Name: NameFull: El-Osta A – PersonEntity: Name: NameFull: Hull-Meichle RL – PersonEntity: Name: NameFull: Zraika S – PersonEntity: Name: NameFull: Kahn SE IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: 2026 Aug Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1432-0428 Numbering: – Type: volume Value: 69 – Type: issue Value: 8 Titles: – TitleFull: Diabetologia Type: main |
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