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The Role of HGF/c-Met/PI3K/AKT Pathway Regulated by α7-nAChR/β2-AR in Nicotine-Promoted Malignant Progression of Nonsmall Cell Lung Cancer A549 Cells.

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Title: The Role of HGF/c-Met/PI3K/AKT Pathway Regulated by α7-nAChR/β2-AR in Nicotine-Promoted Malignant Progression of Nonsmall Cell Lung Cancer A549 Cells.
Authors: Li Z; School of Public Health, Jiangxi Medical College, Nanchang University, No. 461 Ba Yi Avenue, Nanchang, Jiangxi 330006, P. R. of China.; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, No. 461 Ba Yi Avenue, Nanchang, Jiangxi 330006, P. R. of China.; Chongqing Research Institute of Nanchang University, Tai Bai Road, Tongnan, Chongqing 402679, P. R. of China., Xie B; School of Public Health, Jiangxi Medical College, Nanchang University, No. 461 Ba Yi Avenue, Nanchang, Jiangxi 330006, P. R. of China.; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, No. 461 Ba Yi Avenue, Nanchang, Jiangxi 330006, P. R. of China.; Chongqing Research Institute of Nanchang University, Tai Bai Road, Tongnan, Chongqing 402679, P. R. of China., Liu X; School of Public Health, Jiangxi Medical College, Nanchang University, No. 461 Ba Yi Avenue, Nanchang, Jiangxi 330006, P. R. of China.; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, No. 461 Ba Yi Avenue, Nanchang, Jiangxi 330006, P. R. of China.; Chongqing Research Institute of Nanchang University, Tai Bai Road, Tongnan, Chongqing 402679, P. R. of China., He Z; School of Public Health, Jiangxi Medical College, Nanchang University, No. 461 Ba Yi Avenue, Nanchang, Jiangxi 330006, P. R. of China.; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, No. 461 Ba Yi Avenue, Nanchang, Jiangxi 330006, P. R. of China.; Chongqing Research Institute of Nanchang University, Tai Bai Road, Tongnan, Chongqing 402679, P. R. of China., Zhang Z; School of Public Health, Jiangxi Medical College, Nanchang University, No. 461 Ba Yi Avenue, Nanchang, Jiangxi 330006, P. R. of China.; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, No. 461 Ba Yi Avenue, Nanchang, Jiangxi 330006, P. R. of China.; Chongqing Research Institute of Nanchang University, Tai Bai Road, Tongnan, Chongqing 402679, P. R. of China., Zhou J; School of Public Health, Jiangxi Medical College, Nanchang University, No. 461 Ba Yi Avenue, Nanchang, Jiangxi 330006, P. R. of China.; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, No. 461 Ba Yi Avenue, Nanchang, Jiangxi 330006, P. R. of China.; Chongqing Research Institute of Nanchang University, Tai Bai Road, Tongnan, Chongqing 402679, P. R. of China., Zhou T; School of Public Health, Jiangxi Medical College, Nanchang University, No. 461 Ba Yi Avenue, Nanchang, Jiangxi 330006, P. R. of China.; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, No. 461 Ba Yi Avenue, Nanchang, Jiangxi 330006, P. R. of China.; Chongqing Research Institute of Nanchang University, Tai Bai Road, Tongnan, Chongqing 402679, P. R. of China., Wang H; School of Public Health, Jiangxi Medical College, Nanchang University, No. 461 Ba Yi Avenue, Nanchang, Jiangxi 330006, P. R. of China.; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, No. 461 Ba Yi Avenue, Nanchang, Jiangxi 330006, P. R. of China.; Chongqing Research Institute of Nanchang University, Tai Bai Road, Tongnan, Chongqing 402679, P. R. of China.
Source: Chemical research in toxicology [Chem Res Toxicol] 2026 Jun 15; Vol. 39 (6), pp. 1088-1101. Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 8807448 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5010 (Electronic) Linking ISSN: 0893228X NLM ISO Abbreviation: Chem Res Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-5010
DOI:10.1021/acs.chemrestox.5c00464