Epigenomic profiling of neuroendocrine lung cancers identifies a classical-neuroendocrine ASCL1/NKX2-1 subtype and a SOX11-associated differentiation axis linked to reduced immunogenicity.
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| Title: | Epigenomic profiling of neuroendocrine lung cancers identifies a classical-neuroendocrine ASCL1/NKX2-1 subtype and a SOX11-associated differentiation axis linked to reduced immunogenicity. |
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| Authors: | Sato T; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. Electronic address: tsato@med.kitasato-u.ac.jp., Hamamoto J; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan., Emoto K; Department of Pathology, Keio University School of Medicine, Tokyo, Japan., Nagashio R; Department of Molecular Diagnostics, Kitasato University School of Allied Health Sciences, Sagamihara, Japan., Yagami Y; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan., Yamamoto H; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan., Inoue R; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan., Matsuo H; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan., Shirasawa M; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan., Kuchitsu Y; Department of Molecular Diagnostics, Kitasato University School of Allied Health Sciences, Sagamihara, Japan., Kawano S; Department of Data Science, Kitasato University School of Frontier Engineering, Sagamihara, Japan., Hara Y; Department of Data Science, Kitasato University School of Frontier Engineering, Sagamihara, Japan., Yoo S; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States., Fukushima T; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan., Sugihara K; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan., Terai H; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan., Sanoyama I; Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan., Murakumo Y; Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan., Domoto H; Department of Pathology, Keiyu Hospital, Yokohama, Japan., Haraguchi-Hashiguchi M; Division of Pulmonary Medicine, Department of Medicine, Keiyu Hospital, Yokohama, Japan., Shiomi K; Department of Thoracic Surgery, Kitasato University School of Medicine, Sagamihara, Japan., Mikubo M; Department of Thoracic Surgery, Kitasato University School of Medicine, Sagamihara, Japan., Yasuda H; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan., Watanabe H; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States., Naoki K; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan. |
| Source: | Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2026 Jul; Vol. 217, pp. 109464. Date of Electronic Publication: 2026 May 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8800805 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8332 (Electronic) Linking ISSN: 01695002 NLM ISO Abbreviation: Lung Cancer Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42160949 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Epigenomic profiling of neuroendocrine lung cancers identifies a classical-neuroendocrine ASCL1/NKX2-1 subtype and a SOX11-associated differentiation axis linked to reduced immunogenicity. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Sato+T%22">Sato T</searchLink>; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. Electronic address: tsato@med.kitasato-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Hamamoto+J%22">Hamamoto J</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Emoto+K%22">Emoto K</searchLink>; Department of Pathology, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nagashio+R%22">Nagashio R</searchLink>; Department of Molecular Diagnostics, Kitasato University School of Allied Health Sciences, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Yagami+Y%22">Yagami Y</searchLink>; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+H%22">Yamamoto H</searchLink>; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Inoue+R%22">Inoue R</searchLink>; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuo+H%22">Matsuo H</searchLink>; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Shirasawa+M%22">Shirasawa M</searchLink>; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Kuchitsu+Y%22">Kuchitsu Y</searchLink>; Department of Molecular Diagnostics, Kitasato University School of Allied Health Sciences, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Kawano+S%22">Kawano S</searchLink>; Department of Data Science, Kitasato University School of Frontier Engineering, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Hara+Y%22">Hara Y</searchLink>; Department of Data Science, Kitasato University School of Frontier Engineering, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Yoo+S%22">Yoo S</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States.<br /><searchLink fieldCode="AU" term="%22Fukushima+T%22">Fukushima T</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sugihara+K%22">Sugihara K</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Terai+H%22">Terai H</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sanoyama+I%22">Sanoyama I</searchLink>; Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Murakumo+Y%22">Murakumo Y</searchLink>; Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Domoto+H%22">Domoto H</searchLink>; Department of Pathology, Keiyu Hospital, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Haraguchi-Hashiguchi+M%22">Haraguchi-Hashiguchi M</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keiyu Hospital, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Shiomi+K%22">Shiomi K</searchLink>; Department of Thoracic Surgery, Kitasato University School of Medicine, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Mikubo+M%22">Mikubo M</searchLink>; Department of Thoracic Surgery, Kitasato University School of Medicine, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Yasuda+H%22">Yasuda H</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+H%22">Watanabe H</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States.<br /><searchLink fieldCode="AU" term="%22Naoki+K%22">Naoki K</searchLink>; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228800805%22">Lung cancer (Amsterdam, Netherlands)</searchLink> [Lung Cancer] 2026 Jul; Vol. 217, pp. 109464. <i>Date of Electronic Publication: </i>2026 May 18. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Scientific+Publishers%22">Elsevier Scientific Publishers </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>8800805 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-8332 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201695002%22">01695002 </searchLink><i>NLM ISO Abbreviation: </i>Lung Cancer <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42160949 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.lungcan.2026.109464 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 109464 Titles: – TitleFull: Epigenomic profiling of neuroendocrine lung cancers identifies a classical-neuroendocrine ASCL1/NKX2-1 subtype and a SOX11-associated differentiation axis linked to reduced immunogenicity. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sato T – PersonEntity: Name: NameFull: Hamamoto J – PersonEntity: Name: NameFull: Emoto K – PersonEntity: Name: NameFull: Nagashio R – PersonEntity: Name: NameFull: Yagami Y – PersonEntity: Name: NameFull: Yamamoto H – PersonEntity: Name: NameFull: Inoue R – PersonEntity: Name: NameFull: Matsuo H – PersonEntity: Name: NameFull: Shirasawa M – PersonEntity: Name: NameFull: Kuchitsu Y – PersonEntity: Name: NameFull: Kawano S – PersonEntity: Name: NameFull: Hara Y – PersonEntity: Name: NameFull: Yoo S – PersonEntity: Name: NameFull: Fukushima T – PersonEntity: Name: NameFull: Sugihara K – PersonEntity: Name: NameFull: Terai H – PersonEntity: Name: NameFull: Sanoyama I – PersonEntity: Name: NameFull: Murakumo Y – PersonEntity: Name: NameFull: Domoto H – PersonEntity: Name: NameFull: Haraguchi-Hashiguchi M – PersonEntity: Name: NameFull: Shiomi K – PersonEntity: Name: NameFull: Mikubo M – PersonEntity: Name: NameFull: Yasuda H – PersonEntity: Name: NameFull: Watanabe H – PersonEntity: Name: NameFull: Naoki K IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2026 Jul Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1872-8332 Numbering: – Type: volume Value: 217 Titles: – TitleFull: Lung cancer (Amsterdam, Netherlands) Type: main |
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