Epigenomic profiling of neuroendocrine lung cancers identifies a classical-neuroendocrine ASCL1/NKX2-1 subtype and a SOX11-associated differentiation axis linked to reduced immunogenicity.
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| Title: | Epigenomic profiling of neuroendocrine lung cancers identifies a classical-neuroendocrine ASCL1/NKX2-1 subtype and a SOX11-associated differentiation axis linked to reduced immunogenicity. |
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| Authors: | Sato T; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. Electronic address: tsato@med.kitasato-u.ac.jp., Hamamoto J; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan., Emoto K; Department of Pathology, Keio University School of Medicine, Tokyo, Japan., Nagashio R; Department of Molecular Diagnostics, Kitasato University School of Allied Health Sciences, Sagamihara, Japan., Yagami Y; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan., Yamamoto H; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan., Inoue R; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan., Matsuo H; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan., Shirasawa M; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan., Kuchitsu Y; Department of Molecular Diagnostics, Kitasato University School of Allied Health Sciences, Sagamihara, Japan., Kawano S; Department of Data Science, Kitasato University School of Frontier Engineering, Sagamihara, Japan., Hara Y; Department of Data Science, Kitasato University School of Frontier Engineering, Sagamihara, Japan., Yoo S; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States., Fukushima T; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan., Sugihara K; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan., Terai H; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan., Sanoyama I; Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan., Murakumo Y; Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan., Domoto H; Department of Pathology, Keiyu Hospital, Yokohama, Japan., Haraguchi-Hashiguchi M; Division of Pulmonary Medicine, Department of Medicine, Keiyu Hospital, Yokohama, Japan., Shiomi K; Department of Thoracic Surgery, Kitasato University School of Medicine, Sagamihara, Japan., Mikubo M; Department of Thoracic Surgery, Kitasato University School of Medicine, Sagamihara, Japan., Yasuda H; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan., Watanabe H; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States., Naoki K; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan. |
| Source: | Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2026 Jul; Vol. 217, pp. 109464. Date of Electronic Publication: 2026 May 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8800805 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8332 (Electronic) Linking ISSN: 01695002 NLM ISO Abbreviation: Lung Cancer Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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