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Sex-based effectiveness in buprenorphine/naloxone and methadone treatment for opioid use disorder: Findings from the OPTIMA trial.

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Title: Sex-based effectiveness in buprenorphine/naloxone and methadone treatment for opioid use disorder: Findings from the OPTIMA trial.
Authors: McAnulty C; Department of Psychiatry and Addictology, Faculty of Medicine, Université de Montréal, 2900 boul. Edouard-Montpetit, Montréal, Québec H3T 1J4, Canada; Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint-Denis Street, Montréal, Québec H2X 0A9, Canada., Bastien G; Department of Psychiatry and Addictology, Faculty of Medicine, Université de Montréal, 2900 boul. Edouard-Montpetit, Montréal, Québec H3T 1J4, Canada; Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint-Denis Street, Montréal, Québec H2X 0A9, Canada., Pek C; Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint-Denis Street, Montréal, Québec H2X 0A9, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, 2900 boul. Edouard-Montpetit, Montréal, Québec H3T 1J4, Canada., Pelletier McCrea T; Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint-Denis Street, Montréal, Québec H2X 0A9, Canada; Couple and Family Therapy Program, School of Social Work, McGill University, 550 Sherbrooke Ouest, Suite 100, Tour Est, Montreal, Quebec H3A 1B9, Canada., Bouthillier A; Department of Psychiatry and Addictology, Faculty of Medicine, Université de Montréal, 2900 boul. Edouard-Montpetit, Montréal, Québec H3T 1J4, Canada; Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint-Denis Street, Montréal, Québec H2X 0A9, Canada., Stewart SH; Department of Psychiatry, Dalhousie University, QEII Health Sciences Centre, 5909 Veterans' Memorial Lane - 8th floor - Abbie J Lane Memorial Building, Halifax, Nova Scotia, B3H 2E2 Canada; Department of Psychiatry & Neuroscience, Dalhousie University, Life Sciences Centre, 6287 Alumni Crescent - 3rd floor Room 3263 - Halifax, Nova Scotia B3H 4R2, Canada., Socias ME; British Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, British Columbia V6Z 2A9, Canada; Department of Medicine, Faculty of Medicine, University of British Columbia, 1045 Howe Street, Vancouver, British Columbia V6Z 2A9, Canada., Le Foll B; Department of Family and Community Medicine, Faculty of Medicine, University of Toronto, 500 University Avenue, 5th floor, Toronto, Ontario M5G 1V7, Canada; Department of Psychiatry, University of Toronto, 250 College Street, 8th floor, Toronto, Ontario M5T 1R8, Canada; Dalla Lana School of Public Health, University of Toronto, 155 College Street, Ontario, Toronto M5T 3M7, Canada; Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health (CAMH), 33 Ursula Franklin Street, Ontario, Toronto M5S 2S1, Canada; Department of Pharmacology and Toxicology, Faculty of Medicine, Medical Sciences Building, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada; Waypoint Research Institute, Waypoint Centre for Mental Health Care, 500 Church Street, Penetanguishene, Ontario L9M 1G3, Canada., Jutras-Aswad D; Department of Psychiatry and Addictology, Faculty of Medicine, Université de Montréal, 2900 boul. Edouard-Montpetit, Montréal, Québec H3T 1J4, Canada; Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint-Denis Street, Montréal, Québec H2X 0A9, Canada. Electronic address: didier.jutras-aswad@umontreal.ca.
Corporate Authors: OPTIMA Research Group within the Canadian Research Initiative in Substance Misuse
Source: Drug and alcohol dependence [Drug Alcohol Depend] 2026 Aug 01; Vol. 285, pp. 113190. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Pragmatic Clinical Trial
Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 7513587 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0046 (Electronic) Linking ISSN: 03768716 NLM ISO Abbreviation: Drug Alcohol Depend Subsets: MEDLINE
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  Data: Sex-based effectiveness in buprenorphine/naloxone and methadone treatment for opioid use disorder: Findings from the OPTIMA trial.
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  Data: <searchLink fieldCode="AU" term="%22McAnulty+C%22">McAnulty C</searchLink>; Department of Psychiatry and Addictology, Faculty of Medicine, Université de Montréal, 2900 boul. Edouard-Montpetit, Montréal, Québec H3T 1J4, Canada; Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint-Denis Street, Montréal, Québec H2X 0A9, Canada.<br /><searchLink fieldCode="AU" term="%22Bastien+G%22">Bastien G</searchLink>; Department of Psychiatry and Addictology, Faculty of Medicine, Université de Montréal, 2900 boul. Edouard-Montpetit, Montréal, Québec H3T 1J4, Canada; Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint-Denis Street, Montréal, Québec H2X 0A9, Canada.<br /><searchLink fieldCode="AU" term="%22Pek+C%22">Pek C</searchLink>; Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint-Denis Street, Montréal, Québec H2X 0A9, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, 2900 boul. Edouard-Montpetit, Montréal, Québec H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Pelletier+McCrea+T%22">Pelletier McCrea T</searchLink>; Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint-Denis Street, Montréal, Québec H2X 0A9, Canada; Couple and Family Therapy Program, School of Social Work, McGill University, 550 Sherbrooke Ouest, Suite 100, Tour Est, Montreal, Quebec H3A 1B9, Canada.<br /><searchLink fieldCode="AU" term="%22Bouthillier+A%22">Bouthillier A</searchLink>; Department of Psychiatry and Addictology, Faculty of Medicine, Université de Montréal, 2900 boul. Edouard-Montpetit, Montréal, Québec H3T 1J4, Canada; Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint-Denis Street, Montréal, Québec H2X 0A9, Canada.<br /><searchLink fieldCode="AU" term="%22Stewart+SH%22">Stewart SH</searchLink>; Department of Psychiatry, Dalhousie University, QEII Health Sciences Centre, 5909 Veterans' Memorial Lane - 8th floor - Abbie J Lane Memorial Building, Halifax, Nova Scotia, B3H 2E2 Canada; Department of Psychiatry & Neuroscience, Dalhousie University, Life Sciences Centre, 6287 Alumni Crescent - 3rd floor Room 3263 - Halifax, Nova Scotia B3H 4R2, Canada.<br /><searchLink fieldCode="AU" term="%22Socias+ME%22">Socias ME</searchLink>; British Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, British Columbia V6Z 2A9, Canada; Department of Medicine, Faculty of Medicine, University of British Columbia, 1045 Howe Street, Vancouver, British Columbia V6Z 2A9, Canada.<br /><searchLink fieldCode="AU" term="%22Le+Foll+B%22">Le Foll B</searchLink>; Department of Family and Community Medicine, Faculty of Medicine, University of Toronto, 500 University Avenue, 5th floor, Toronto, Ontario M5G 1V7, Canada; Department of Psychiatry, University of Toronto, 250 College Street, 8th floor, Toronto, Ontario M5T 1R8, Canada; Dalla Lana School of Public Health, University of Toronto, 155 College Street, Ontario, Toronto M5T 3M7, Canada; Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health (CAMH), 33 Ursula Franklin Street, Ontario, Toronto M5S 2S1, Canada; Department of Pharmacology and Toxicology, Faculty of Medicine, Medical Sciences Building, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada; Waypoint Research Institute, Waypoint Centre for Mental Health Care, 500 Church Street, Penetanguishene, Ontario L9M 1G3, Canada.<br /><searchLink fieldCode="AU" term="%22Jutras-Aswad+D%22">Jutras-Aswad D</searchLink>; Department of Psychiatry and Addictology, Faculty of Medicine, Université de Montréal, 2900 boul. Edouard-Montpetit, Montréal, Québec H3T 1J4, Canada; Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint-Denis Street, Montréal, Québec H2X 0A9, Canada. Electronic address: didier.jutras-aswad@umontreal.ca.
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  Data: <searchLink fieldCode="JN" term="%227513587%22">Drug and alcohol dependence</searchLink> [Drug Alcohol Depend] 2026 Aug 01; Vol. 285, pp. 113190. <i>Date of Electronic Publication: </i>2026 May 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>7513587 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0046 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203768716%22">03768716 </searchLink><i>NLM ISO Abbreviation: </i>Drug Alcohol Depend <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.drugalcdep.2026.113190
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        Text: English
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