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Intrinsic bias of the genetic code shapes the folding and stability landscapes of microproteins.

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Title: Intrinsic bias of the genetic code shapes the folding and stability landscapes of microproteins.
Authors: Guo Y; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China., Qin T; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Center for Evolutionary & Organismal Biology, Zhejiang University School of Medicine, Hangzhou 310058, China., Luo J; College of Life Sciences, Zhejiang University, Hangzhou 310027, China; The Provincial International Science and Technology Cooperation Base on Engineering Biology, International Campus of Zhejiang University, Haining 314400, China., Pan Q; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China., Shu R; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China., Guo R; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China., Qian J; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China., Xu C; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China., Wang J; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China., Wang Z; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China., Zheng N; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China., Li H; Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China., Guo X; Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China., Cao X; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai 200241, China., Wang Y; College of Life Sciences, Zhejiang University, Hangzhou 310027, China; The Provincial International Science and Technology Cooperation Base on Engineering Biology, International Campus of Zhejiang University, Haining 314400, China. Electronic address: yongwang_isb@zju.edu.cn., Zhang S; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: shanzhang@zju.edu.cn.
Source: Molecular cell [Mol Cell] 2026 Jun 04; Vol. 86 (11), pp. 2173-2190.e11. Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Guo+Y%22">Guo Y</searchLink>; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Qin+T%22">Qin T</searchLink>; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Center for Evolutionary & Organismal Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Luo+J%22">Luo J</searchLink>; College of Life Sciences, Zhejiang University, Hangzhou 310027, China; The Provincial International Science and Technology Cooperation Base on Engineering Biology, International Campus of Zhejiang University, Haining 314400, China.<br /><searchLink fieldCode="AU" term="%22Pan+Q%22">Pan Q</searchLink>; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Shu+R%22">Shu R</searchLink>; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Guo+R%22">Guo R</searchLink>; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Qian+J%22">Qian J</searchLink>; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Zheng+N%22">Zheng N</searchLink>; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.<br /><searchLink fieldCode="AU" term="%22Guo+X%22">Guo X</searchLink>; Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.<br /><searchLink fieldCode="AU" term="%22Cao+X%22">Cao X</searchLink>; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai 200241, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; College of Life Sciences, Zhejiang University, Hangzhou 310027, China; The Provincial International Science and Technology Cooperation Base on Engineering Biology, International Campus of Zhejiang University, Haining 314400, China. Electronic address: yongwang_isb@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Department of Biochemistry, Department of Cardiology of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: shanzhang@zju.edu.cn.
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        Value: 10.1016/j.molcel.2026.04.021
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        Text: English
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              Text: 2026 Jun 04
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