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Structural and mechanistic insights into the constitutive Themis-Grb2 complex in T cell signalling.

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Title: Structural and mechanistic insights into the constitutive Themis-Grb2 complex in T cell signalling.
Authors: Clancy DM; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium. danielle.clancy@irc.vib-ugent.be.; VIB Center for Inflammation Research, Ghent, Belgium. danielle.clancy@irc.vib-ugent.be., Sanz-Sanjuan A; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent, Belgium., Gilis E; VIB Center for Inflammation Research, Ghent, Belgium.; Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium., Tougaard P; VIB Center for Inflammation Research, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Velghe I; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Van Droogenbroeck Y; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Felix J; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent, Belgium., Bloch Y; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent, Belgium.; European Molecular Biology Laboratory, Hamburg Unit c/o DESY, Hamburg, Germany., Cuadrado ÁF; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent, Belgium., Merceron R; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent, Belgium.; Eurofins DiscoverX Products France, Celle-Lévescault, France., Schenck S; VIB-VUB Center for Structural Biology, VIB, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, 1050, Brussels, Belgium., Vandenabeele P; VIB Center for Inflammation Research, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Brunner JD; VIB-VUB Center for Structural Biology, VIB, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, 1050, Brussels, Belgium., Taghon T; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Elewaut D; VIB Center for Inflammation Research, Ghent, Belgium.; Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium., Savvides SN; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium. savvas.savvides@ugent.be.; VIB Center for Inflammation Research, Ghent, Belgium. savvas.savvides@ugent.be.
Source: Nature communications [Nat Commun] 2026 May 20; Vol. 17 (1). Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Clancy+DM%22">Clancy DM</searchLink>; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium. danielle.clancy@irc.vib-ugent.be.; VIB Center for Inflammation Research, Ghent, Belgium. danielle.clancy@irc.vib-ugent.be.<br /><searchLink fieldCode="AU" term="%22Sanz-Sanjuan+A%22">Sanz-Sanjuan A</searchLink>; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Gilis+E%22">Gilis E</searchLink>; VIB Center for Inflammation Research, Ghent, Belgium.; Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Tougaard+P%22">Tougaard P</searchLink>; VIB Center for Inflammation Research, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Velghe+I%22">Velghe I</searchLink>; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+Droogenbroeck+Y%22">Van Droogenbroeck Y</searchLink>; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Felix+J%22">Felix J</searchLink>; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Bloch+Y%22">Bloch Y</searchLink>; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent, Belgium.; European Molecular Biology Laboratory, Hamburg Unit c/o DESY, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Cuadrado+ÁF%22">Cuadrado ÁF</searchLink>; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Merceron+R%22">Merceron R</searchLink>; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent, Belgium.; Eurofins DiscoverX Products France, Celle-Lévescault, France.<br /><searchLink fieldCode="AU" term="%22Schenck+S%22">Schenck S</searchLink>; VIB-VUB Center for Structural Biology, VIB, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, 1050, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Vandenabeele+P%22">Vandenabeele P</searchLink>; VIB Center for Inflammation Research, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Brunner+JD%22">Brunner JD</searchLink>; VIB-VUB Center for Structural Biology, VIB, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, 1050, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Taghon+T%22">Taghon T</searchLink>; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Elewaut+D%22">Elewaut D</searchLink>; VIB Center for Inflammation Research, Ghent, Belgium.; Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Savvides+SN%22">Savvides SN</searchLink>; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium. savvas.savvides@ugent.be.; VIB Center for Inflammation Research, Ghent, Belgium. savvas.savvides@ugent.be.
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