Structural and mechanistic insights into the constitutive Themis-Grb2 complex in T cell signalling.
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| Title: | Structural and mechanistic insights into the constitutive Themis-Grb2 complex in T cell signalling. |
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| Authors: | Clancy DM; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium. danielle.clancy@irc.vib-ugent.be.; VIB Center for Inflammation Research, Ghent, Belgium. danielle.clancy@irc.vib-ugent.be., Sanz-Sanjuan A; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent, Belgium., Gilis E; VIB Center for Inflammation Research, Ghent, Belgium.; Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium., Tougaard P; VIB Center for Inflammation Research, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Velghe I; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Van Droogenbroeck Y; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Felix J; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent, Belgium., Bloch Y; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent, Belgium.; European Molecular Biology Laboratory, Hamburg Unit c/o DESY, Hamburg, Germany., Cuadrado ÁF; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent, Belgium., Merceron R; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent, Belgium.; Eurofins DiscoverX Products France, Celle-Lévescault, France., Schenck S; VIB-VUB Center for Structural Biology, VIB, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, 1050, Brussels, Belgium., Vandenabeele P; VIB Center for Inflammation Research, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Brunner JD; VIB-VUB Center for Structural Biology, VIB, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, 1050, Brussels, Belgium., Taghon T; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Elewaut D; VIB Center for Inflammation Research, Ghent, Belgium.; Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium., Savvides SN; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium. savvas.savvides@ugent.be.; VIB Center for Inflammation Research, Ghent, Belgium. savvas.savvides@ugent.be. |
| Source: | Nature communications [Nat Commun] 2026 May 20; Vol. 17 (1). Date of Electronic Publication: 2026 May 20. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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