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Autoinhibitory feedback preserves intestinal stem cell maintenance and fate commitment.

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Title: Autoinhibitory feedback preserves intestinal stem cell maintenance and fate commitment.
Authors: Redhai S; German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg, Germany. siamak.redhai@dkfz.de.; Heidelberg University, Institute of Human Genetics, Medical Faculty Heidelberg, Heidelberg, Germany. siamak.redhai@dkfz.de.; Heidelberg University, Department of Cell and Molecular Biology, Medical Faculty Mannheim & BioQuant, Heidelberg, Germany. siamak.redhai@dkfz.de., Hirschmüller N; European Molecular Biology Laboratory (EMBL), Meyerhofstraße 1, Heidelberg, Germany.; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Wang T; German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg, Germany.; Heidelberg University, Institute of Human Genetics, Medical Faculty Heidelberg, Heidelberg, Germany.; Heidelberg University, Department of Cell and Molecular Biology, Medical Faculty Mannheim & BioQuant, Heidelberg, Germany., Jackson T; Huffington Center on Aging & Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Peidli S; European Molecular Biology Laboratory (EMBL), Meyerhofstraße 1, Heidelberg, Germany., Valentini E; German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg, Germany.; Heidelberg University, Institute of Human Genetics, Medical Faculty Heidelberg, Heidelberg, Germany.; Heidelberg University, Department of Cell and Molecular Biology, Medical Faculty Mannheim & BioQuant, Heidelberg, Germany., Bahuguna S; German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg, Germany.; Heidelberg University, Institute of Human Genetics, Medical Faculty Heidelberg, Heidelberg, Germany.; Heidelberg University, Department of Cell and Molecular Biology, Medical Faculty Mannheim & BioQuant, Heidelberg, Germany., Leible S; German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg, Germany.; Heidelberg University, Institute of Human Genetics, Medical Faculty Heidelberg, Heidelberg, Germany.; Heidelberg University, Department of Cell and Molecular Biology, Medical Faculty Mannheim & BioQuant, Heidelberg, Germany., Möller S; German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg, Germany.; Heidelberg University, Institute of Human Genetics, Medical Faculty Heidelberg, Heidelberg, Germany., Ko C; BioSciences Department, Rice University, Houston, TX, USA., Holzem M; German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg, Germany.; Heidelberg University, Institute of Human Genetics, Medical Faculty Heidelberg, Heidelberg, Germany.; Heidelberg University, Department of Cell and Molecular Biology, Medical Faculty Mannheim & BioQuant, Heidelberg, Germany., Kharuk S; European Molecular Biology Laboratory (EMBL), Meyerhofstraße 1, Heidelberg, Germany.; Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine., Bräckow L; German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg, Germany.; Heidelberg University, Department of Cell and Molecular Biology, Medical Faculty Mannheim & BioQuant, Heidelberg, Germany., Port F; German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg, Germany.; Heidelberg University, Institute of Human Genetics, Medical Faculty Heidelberg, Heidelberg, Germany.; Heidelberg University, Department of Cell and Molecular Biology, Medical Faculty Mannheim & BioQuant, Heidelberg, Germany., Ibberson D; Cellnetworks Core Technology Platform (CCTP), Deep Sequencing Labor, Heidelberg, Germany., Le H; Huffington Center on Aging & Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Huber W; European Molecular Biology Laboratory (EMBL), Meyerhofstraße 1, Heidelberg, Germany. wolfgang.huber@embl.org., Boutros M; German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg, Germany. m.boutros@dkfz.de.; Heidelberg University, Institute of Human Genetics, Medical Faculty Heidelberg, Heidelberg, Germany. m.boutros@dkfz.de.; Heidelberg University, Department of Cell and Molecular Biology, Medical Faculty Mannheim & BioQuant, Heidelberg, Germany. m.boutros@dkfz.de.
Source: The EMBO journal [EMBO J] 2026 Jul; Vol. 45 (13), pp. 4636-4669. Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
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  Data: Autoinhibitory feedback preserves intestinal stem cell maintenance and fate commitment.
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  Data: <searchLink fieldCode="AU" term="%22Redhai+S%22">Redhai S</searchLink>; German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg, Germany. siamak.redhai@dkfz.de.; Heidelberg University, Institute of Human Genetics, Medical Faculty Heidelberg, Heidelberg, Germany. siamak.redhai@dkfz.de.; Heidelberg University, Department of Cell and Molecular Biology, Medical Faculty Mannheim & BioQuant, Heidelberg, Germany. siamak.redhai@dkfz.de.<br /><searchLink fieldCode="AU" term="%22Hirschmüller+N%22">Hirschmüller N</searchLink>; European Molecular Biology Laboratory (EMBL), Meyerhofstraße 1, Heidelberg, Germany.; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg, Germany.; Heidelberg University, Institute of Human Genetics, Medical Faculty Heidelberg, Heidelberg, Germany.; 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Heidelberg University, Department of Cell and Molecular Biology, Medical Faculty Mannheim & BioQuant, Heidelberg, Germany. m.boutros@dkfz.de.
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