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Mitochondrial L-2-hydroxyglutarate is a physiological signalling metabolite.

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Title: Mitochondrial L-2-hydroxyglutarate is a physiological signalling metabolite.
Authors: Chakrabarty RP; Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Van Vranken JG; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Aoi Y; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Poor TA; Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., McElroy GS; Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Vasan K; Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Soliman SHA; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Iwanaszko M; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Grant RA; Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Howard BC; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Reczek CR; Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Chandel AD; Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Kahl M; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA., Xu Z; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA., Helmin KA; Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Jin Q; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Wang D; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Gao P; Metabolomics Core Facility of RHLCCC, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Blum JLE; Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Sebo ZL; Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Yue F; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Ma YC; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA., Davidson SM; Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Weinberg SE; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Singer BD; Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Han S; Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Shilatifard A; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Biohub, Chicago, IL, USA., Chandel NS; Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. nav@northwestern.edu.; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. nav@northwestern.edu.; Biohub, Chicago, IL, USA. nav@northwestern.edu.
Source: Nature [Nature] 2026 Jul; Vol. 655 (8124), pp. 1037-1047. Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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