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Gold-containing compounds target an apicomplexan Thioredoxin reductase: Disclosing reactivity through structural and functional characterization.

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Title: Gold-containing compounds target an apicomplexan Thioredoxin reductase: Disclosing reactivity through structural and functional characterization.
Authors: Gabriele F; Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100, L'Aquila, Italy., Palerma M; Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100, L'Aquila, Italy; Department of Science, Technology and Society, University School for Advanced Studies of Pavia, Pavia, 27100, Italy., Bogard J; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, 60612, United States., Paluzzi L; Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100, L'Aquila, Italy; Department of Science, Technology and Society, University School for Advanced Studies of Pavia, Pavia, 27100, Italy., Zineddu S; Department of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3-13, Sesto Fiorentino, 50019, Italy., Geri A; Department of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3-13, Sesto Fiorentino, 50019, Italy., Vitali V; Department of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3-13, Sesto Fiorentino, 50019, Italy., Massai L; Department of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3-13, Sesto Fiorentino, 50019, Italy., Ardini M; Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100, L'Aquila, Italy., Bellelli A; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Rome, 00185, Italy., Petukhov PA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, IL, 60612, United States., Ippoliti R; Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100, L'Aquila, Italy., Messori L; Department of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3-13, Sesto Fiorentino, 50019, Italy., Williams DL; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, 60612, United States., Angelucci F; Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100, L'Aquila, Italy. Electronic address: francesco.angelucci@univaq.it.
Source: International journal of biological macromolecules [Int J Biol Macromol] 2026 Jun; Vol. 369, pp. 152627. Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
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  Data: Gold-containing compounds target an apicomplexan Thioredoxin reductase: Disclosing reactivity through structural and functional characterization.
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  Data: <searchLink fieldCode="AU" term="%22Gabriele+F%22">Gabriele F</searchLink>; Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100, L'Aquila, Italy.<br /><searchLink fieldCode="AU" term="%22Palerma+M%22">Palerma M</searchLink>; Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100, L'Aquila, Italy; Department of Science, Technology and Society, University School for Advanced Studies of Pavia, Pavia, 27100, Italy.<br /><searchLink fieldCode="AU" term="%22Bogard+J%22">Bogard J</searchLink>; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, 60612, United States.<br /><searchLink fieldCode="AU" term="%22Paluzzi+L%22">Paluzzi L</searchLink>; Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100, L'Aquila, Italy; Department of Science, Technology and Society, University School for Advanced Studies of Pavia, Pavia, 27100, Italy.<br /><searchLink fieldCode="AU" term="%22Zineddu+S%22">Zineddu S</searchLink>; Department of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3-13, Sesto Fiorentino, 50019, Italy.<br /><searchLink fieldCode="AU" term="%22Geri+A%22">Geri A</searchLink>; Department of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3-13, Sesto Fiorentino, 50019, Italy.<br /><searchLink fieldCode="AU" term="%22Vitali+V%22">Vitali V</searchLink>; Department of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3-13, Sesto Fiorentino, 50019, Italy.<br /><searchLink fieldCode="AU" term="%22Massai+L%22">Massai L</searchLink>; Department of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3-13, Sesto Fiorentino, 50019, Italy.<br /><searchLink fieldCode="AU" term="%22Ardini+M%22">Ardini M</searchLink>; Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100, L'Aquila, Italy.<br /><searchLink fieldCode="AU" term="%22Bellelli+A%22">Bellelli A</searchLink>; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Rome, 00185, Italy.<br /><searchLink fieldCode="AU" term="%22Petukhov+PA%22">Petukhov PA</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, IL, 60612, United States.<br /><searchLink fieldCode="AU" term="%22Ippoliti+R%22">Ippoliti R</searchLink>; Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100, L'Aquila, Italy.<br /><searchLink fieldCode="AU" term="%22Messori+L%22">Messori L</searchLink>; Department of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3-13, Sesto Fiorentino, 50019, Italy.<br /><searchLink fieldCode="AU" term="%22Williams+DL%22">Williams DL</searchLink>; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, 60612, United States.<br /><searchLink fieldCode="AU" term="%22Angelucci+F%22">Angelucci F</searchLink>; Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100, L'Aquila, Italy. Electronic address: francesco.angelucci@univaq.it.
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  Data: <searchLink fieldCode="JN" term="%227909578%22">International journal of biological macromolecules</searchLink> [Int J Biol Macromol] 2026 Jun; Vol. 369, pp. 152627. <i>Date of Electronic Publication: </i>2026 May 19.
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              Text: 2026 Jun
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