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The insulin receptor inhibitor BMS-754807 alleviates neuroinflammation and Alzheimer's disease pathologies across human cellular and mouse models.

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Title: The insulin receptor inhibitor BMS-754807 alleviates neuroinflammation and Alzheimer's disease pathologies across human cellular and mouse models.
Authors: Lee HJ; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-Ro, Daegu, 41062, Republic of Korea.; AI-Based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), 61, Cheomdan-Ro, Daegu, 41062, Republic of Korea., Seok J; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea., Kang S; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-Ro, Daegu, 41062, Republic of Korea.; AI-Based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), 61, Cheomdan-Ro, Daegu, 41062, Republic of Korea., Oh S; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-Ro, Daegu, 41062, Republic of Korea.; AI-Based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), 61, Cheomdan-Ro, Daegu, 41062, Republic of Korea., Hwang JW; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-Ro, Daegu, 41062, Republic of Korea.; AI-Based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), 61, Cheomdan-Ro, Daegu, 41062, Republic of Korea., Kim YJ; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-Ro, Daegu, 41062, Republic of Korea.; AI-Based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), 61, Cheomdan-Ro, Daegu, 41062, Republic of Korea., Seo J; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea. jseo@yonsei.ac.kr., Hoe HS; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-Ro, Daegu, 41062, Republic of Korea. sookhoe72@kbri.re.kr.; AI-Based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), 61, Cheomdan-Ro, Daegu, 41062, Republic of Korea. sookhoe72@kbri.re.kr.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, 42988, Republic of Korea. sookhoe72@kbri.re.kr.
Source: Journal of neuroinflammation [J Neuroinflammation] 2026 May 20; Vol. 23 (1). Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1742-2094
DOI:10.1186/s12974-026-03855-7