Increased mRNA translation delays tumour initiation and exposes a therapeutic vulnerability in lung cancer.

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Title: Increased mRNA translation delays tumour initiation and exposes a therapeutic vulnerability in lung cancer.
Authors: Pardo L; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK. Luis.Pardo-Fernandez@glasgow.ac.uk., Moore M; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Deshmukh R; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Powley I; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK., Waldron JA; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Kruspig B; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK.; Institute of Molecular Biology (IMB), Mainz, 55128, Germany., McGarry L; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Dolma L; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Campos AV; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Wood C; School of Medicine, Dentistry & Nursing, University of Glasgow, Glasgow, G12 8QQ, UK., Leslie H; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK., Hughes M; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Jeldes E; Centre for Inflammation Research, University of Edinburgh, Edinburgh, EH16 4UU, UK., Munro J; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Mitchell L; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Officer-Jones L; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Baird R; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Coquelet H; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Jamieson NB; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK., Sumpton D; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Strathdee D; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., le Quesne J; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK., Bushell M; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK. Martin.Bushell@glasgow.ac.uk.; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK. Martin.Bushell@glasgow.ac.uk., Murphy DJ; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK. Daniel.Murphy@glasgow.ac.uk.; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK. Daniel.Murphy@glasgow.ac.uk., Norman JC; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK. j.norman@crukscotlandinstitute.ac.uk.; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK. j.norman@crukscotlandinstitute.ac.uk.
Source: Molecular cancer [Mol Cancer] 2026 May 21; Vol. 25 (1). Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4598
DOI:10.1186/s12943-026-02680-z