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Increased mRNA translation delays tumour initiation and exposes a therapeutic vulnerability in lung cancer.

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Title: Increased mRNA translation delays tumour initiation and exposes a therapeutic vulnerability in lung cancer.
Authors: Pardo L; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK. Luis.Pardo-Fernandez@glasgow.ac.uk., Moore M; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Deshmukh R; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Powley I; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK., Waldron JA; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Kruspig B; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK.; Institute of Molecular Biology (IMB), Mainz, 55128, Germany., McGarry L; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Dolma L; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Campos AV; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Wood C; School of Medicine, Dentistry & Nursing, University of Glasgow, Glasgow, G12 8QQ, UK., Leslie H; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK., Hughes M; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Jeldes E; Centre for Inflammation Research, University of Edinburgh, Edinburgh, EH16 4UU, UK., Munro J; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Mitchell L; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Officer-Jones L; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Baird R; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Coquelet H; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Jamieson NB; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK., Sumpton D; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., Strathdee D; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK., le Quesne J; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK., Bushell M; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK. Martin.Bushell@glasgow.ac.uk.; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK. Martin.Bushell@glasgow.ac.uk., Murphy DJ; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK. Daniel.Murphy@glasgow.ac.uk.; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK. Daniel.Murphy@glasgow.ac.uk., Norman JC; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK. j.norman@crukscotlandinstitute.ac.uk.; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK. j.norman@crukscotlandinstitute.ac.uk.
Source: Molecular cancer [Mol Cancer] 2026 May 21; Vol. 25 (1). Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE
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  Data: Increased mRNA translation delays tumour initiation and exposes a therapeutic vulnerability in lung cancer.
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  Data: <searchLink fieldCode="AU" term="%22Pardo+L%22">Pardo L</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK. Luis.Pardo-Fernandez@glasgow.ac.uk.<br /><searchLink fieldCode="AU" term="%22Moore+M%22">Moore M</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Deshmukh+R%22">Deshmukh R</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Powley+I%22">Powley I</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK.<br /><searchLink fieldCode="AU" term="%22Waldron+JA%22">Waldron JA</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Kruspig+B%22">Kruspig B</searchLink>; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK.; Institute of Molecular Biology (IMB), Mainz, 55128, Germany.<br /><searchLink fieldCode="AU" term="%22McGarry+L%22">McGarry L</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Dolma+L%22">Dolma L</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Campos+AV%22">Campos AV</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Wood+C%22">Wood C</searchLink>; School of Medicine, Dentistry & Nursing, University of Glasgow, Glasgow, G12 8QQ, UK.<br /><searchLink fieldCode="AU" term="%22Leslie+H%22">Leslie H</searchLink>; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK.<br /><searchLink fieldCode="AU" term="%22Hughes+M%22">Hughes M</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Jeldes+E%22">Jeldes E</searchLink>; Centre for Inflammation Research, University of Edinburgh, Edinburgh, EH16 4UU, UK.<br /><searchLink fieldCode="AU" term="%22Munro+J%22">Munro J</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Mitchell+L%22">Mitchell L</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Officer-Jones+L%22">Officer-Jones L</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Baird+R%22">Baird R</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Coquelet+H%22">Coquelet H</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Jamieson+NB%22">Jamieson NB</searchLink>; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK.<br /><searchLink fieldCode="AU" term="%22Sumpton+D%22">Sumpton D</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Strathdee+D%22">Strathdee D</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22le+Quesne+J%22">le Quesne J</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK.<br /><searchLink fieldCode="AU" term="%22Bushell+M%22">Bushell M</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK. Martin.Bushell@glasgow.ac.uk.; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK. Martin.Bushell@glasgow.ac.uk.<br /><searchLink fieldCode="AU" term="%22Murphy+DJ%22">Murphy DJ</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK. Daniel.Murphy@glasgow.ac.uk.; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK. Daniel.Murphy@glasgow.ac.uk.<br /><searchLink fieldCode="AU" term="%22Norman+JC%22">Norman JC</searchLink>; Cancer Research UK Scotland Institute, Glasgow, G61 1BD, UK. j.norman@crukscotlandinstitute.ac.uk.; School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK. j.norman@crukscotlandinstitute.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101147698%22">Molecular cancer</searchLink> [Mol Cancer] 2026 May 21; Vol. 25 (1). <i>Date of Electronic Publication: </i>2026 May 21.
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